EpistemisModified Duke Criteria for Infective Endocarditis
Required inputs
| Variable | Example value |
|---|---|
| Typical Positive Blood Cultures: Compatible organism isolated in 2 independent blood cultures (e.g., S. aureus , S. viridans , HACEK ), or persistently positive blood culture or a single positive blood culture for Coxiella burnetii . | — |
| Evidence of Endocardial Involvement: Positive echocardiogram showing oscillating vegetations, paravalvular abscess, new-onset prosthetic valve dehiscence, or new-onset valve regurgitation. | — |
| Predisposition: Pre-existing predisposing heart valve disease or intravenous injection drug user. | — |
| Fever: Core body temperature recorded ≥ 38.0 °C (100.4 °F). | — |
| Vascular Phenomena: Major systemic arterial emboli, septic pulmonary infarcts, mycotic aneurysms, intracranial hemorrhage, conjunctival hemorrhages or Janeway lesions. | — |
| Immunological Phenomena: Glomerulonephritis, Osler nodules, Roth spots, or detectable positive rheumatoid factor. | — |
| Minor Microbiological Evidence: Positive blood culture that does not meet the major criterion, or serological evidence of active infection with a compatible organism. | — |
Run the calculation in the app
This page explains the score but does not run it. In Epistemis, the calculator validates units, flags values outside physiological ranges, and provides the interpretation that a number alone cannot convey.
Epistemis is educational review material. It is not a medical device, does not diagnose or prescribe treatment, and does not replace formal medical training, current clinical guidelines, or professional clinical judgment.
- Specialty
- Infectious diseases
- Area
- Internal Medicine
- Variables
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