Allergology — Drug Allergy and Adverse Reactions

Allergology and Immunology · Clinical Specialties

How it begins

Una revisión detallada y de nivel experto sobre las reacciones adversas a medicamentos de base inmunológica e industrial. Este documento abarca la caracterización molecular del hapteno, la presentación antigénica no covalente (p-i), las manifestaciones clínicas graves (SJS/TEN, DRESS, AGEP) y los algoritmos diagnósticos y de desensibilización de acuerdo con las directrices internacionales más recientes de la EAACI,…

What it covers

1. General Classification of ADRs (Adverse Drug Reactions)
2. · Rawlins and Thompson Classification Systems
3. · Expansion of the Classification Spectrum (Types C, D, E and F)
4. Immunological Mechanisms of Drug Hypersensitivity
5. · The Paradox of Low Molecular Weight: Haptenization and Immunogenicity
6. · Associations between HLA Polymorphisms and Serious Reactions
7. Immediate IgE-Mediated Reactions (Type I)
8. · Awareness Phase vs. Effector Phase
9. · Systemic Anaphylaxis: Consensus Diagnostic Criteria
10. · Emergency Treatment of Pharmacological Anaphylaxis
11. Late Reactions Not Mediated by IgE (Types II, III and IV)
12. · Type II Reactions (Drug Cytotoxicity)
13. · Type III Reactions (Serum Sickness and Immune Complexes)
14. · Type IV Reactions (Differentiated Cellular Hypersensitivity)
15. Serious Skin Drug Reactions (SCARs)
16. · 1. Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)
17. · 2. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS / DIHS)
18. · 3. Acute Generalized Exanthematous Pustulosis (AGEP)
19. Hypersensitivity to Beta-lactam Antibiotics
20. · Chemical Structure, Penicillin Determinants and Cross Reactivity
21. · List of Structural Homologies in R1 Side Chains
22. Hypersensitivity to Non-Beta-lactam Antibiotics
23. · 1. Sulfonamides (Sulfamethoxazole)
24. · 2. Quinolones
25. · 3. Glycopeptides: Vancomycin Infusion Reaction (VIR)
26. Hypersensitivity reactions to NSAIDs
27. · ENDA/EAACI Molecular Classification of Hypersensitivity to NSAIDs
28. · Pathophysiology of Cross Reactors: The Imbalance of the Arachidonic Acid Pathway
29. · Proposal for Safe Pharmacological Management for Cross Reactors
30. Hypersensitivity to Radiological Contrast Media
31. · Physical-Chemical Classification of MCR
32. · Mechanism of Immediate Reactions against MCR
33. · Premedication Protocols with Corticosteroids and Antihistamines
34. Hypersensitivity to Chemotherapeutics and Monoclonal Antibodies
35. · 1. Compounds derived from Platinum (Carboplatin, Oxaliplatin, Cisplatin)
36. · 2. Taxanes (Paclitaxel, Docetaxel)
37. · 3. Monoclonal Antibodies (Rituximab, Infliximab, Cetuximab)
38. Perioperative Hypersensitivity and Anesthetics
39. · Neuromuscular Blocking Agents (Muscle Relaxants)
40. · Other Critical Perioperative Culprits
41. In Vivo Diagnostic Methods: Skin and Provocation Tests
42. · Methodology and Maximum Non-Irritant Concentrations
43. · Controlled Provocation Test (DPT - Drug Provocation Test)
44. · Oral Provocation Algorithm for Penicillins / Amoxicillin
45. In Vitro Diagnostic Methods and Pharmacogenomics
46. · 1. Basophil Activation Test by Flow Cytometry (BAT)
47. · 2. Lymphocyte Transformation Test (LTT - Lymphocyte Transformation Test)
48. · 3. Multiplex Cytokine and Direct Cytotoxicity Assays (ELISPOT)
49. Rapid Drug Desensitization Protocols
50. · Molecular and Cellular Basis of Tolerance Induction
51. · Castells Standard Intravenous Desensitization Protocol (12 Steps)