Clinical Biochemistry of Infertility: Pathophysiology, Diagnosis and Biomarkers

Biochemistry · Basic Sciences

How it begins

La infertilidad es un trastorno complejo con base metabólica, genética, inmunológica y endocrina. Este tratado expone de forma exhaustiva los mecanismos de señalización, las vías bioquímicas de la esteroidogénesis, la función gamética y las técnicas de diagnóstico en el laboratorio de reproducción asistida.

What it covers

1. Endocrinology of the Hypothalamic-Pituitary-Gonad (HHG) Axis
2. Oocyte Biochemistry and Regulation of the Ovarian Reserve
3. · The Theory of Two Cells, Two Gonadotropins
4. Biochemical Physiology of Sperm and Seminal Plasma
5. · Molecular Mechanism of Training
6. Advanced Spermogram and Seminal Biochemical Markers
7. · Biochemical Markers of Accessory Glands
8. · Sperm DNA Fragmentation (SDF)
9. Female Endocrine-Metabolic Dysfunctions: PCOS and Endometriosis
10. · Biochemical Pathophysiology of Endometriosis
11. Male Endocrine Dysfunctions and Hypogonadism
12. · Molecular Defects in Leydigian Steroidogenesis
13. Immunological Factors of Infertility
14. · Antisperm Antibodies (ASA)
15. · Natural Killer (NK) Cells: Peripheral vs. Uterine
16. Pathophysiology of Implantation and Receptive Endometrium
17. Biochemistry of Oxidative Stress and Mitochondrial Dysfunction
18. · Antioxidant Defense Systems in the Reproductive Tract
19. Genetics and Epigenetics of Infertility
20. · Y Chromosome Microdeletions
21. · Mutations in the CFTR Gene and Agenesis of the Vas Deferens
22. Hormonometry and Immunoassays in the Reproduction Laboratory
23. · Hook Effect (Prozone Effect)
24. · Interferences by Heterophile Antibodies and Biotin
25. Ovarian Reserve Tests and Folliculogenesis Dynamics
26. · Anti-Müllerian Hormone (AMH) as a Biomarker
27. · Day 3 Classic Endocrine Evaluation
28. Evaluation of the Recurrent Pregnancy Loss Factor (PGR)
29. · Hereditary Thrombophilias: Molecular Physiopathology
30. Biomarkers in Assisted Reproduction Techniques (ART)
31. · Biochemistry of Follicular Fluid
32. · Non-Invasive Metabolomics of Spent Culture Medium (SCM)
33. Unexplained infertility and Endocrine Disruptors
34. · Bisphenol A (BPA) and its Molecular Effects
35. · Phthalates and Leydig Cell Dysfunction
36. Ovarian Stimulation Protocols and their Biochemical Monitoring
37. · Pituitary Blockade Systems: Agonists vs. Antagonists
38. · Pathophysiology of Ovarian Hyperstimulation Syndrome (OHSS)
39. Advanced Sperm Function Tests
40. · Evaluation of the Acrosome Reaction
41. · Hyaluronic Acid (HBA) Binding Assay
42. Clinical Diagnostic Algorithms and Multidisciplinary Integration
43. · Female Infertility Diagnosis Algorithm
44. · Male Infertility Diagnosis Algorithm