Clinical Biochemistry of Sepsis — In-depth Scientific Analysis

Biochemistry · Basic Sciences

How it begins

Estudio avanzado y exhaustivo de la desregulación biológica de la sepsis. Un desglose riguroso de las cascadas de señalización inmunometabólicas, alteraciones endoteliales y mitocondriales, biomarcadores de última generación, y la aplicación del análisis molecular en medicina de precisión.

What it covers

1. Definitions and Evolution of Clinical-Biochemical Criteria (Sepsis-3)
2. Pathogen Recognition Mechanisms: PAMPs, DAMPs and PRRs
3. Intracellular Signaling in Sepsis: NF-κB, MAPK and IRF Pathways
4. The Cytokine Storm: Kinetics and Mechanisms of Action
5. Endothelial Dysfunction: Vascular Glycocalyx, Permeability and Nitric Oxide
6. Immunopathology of Sepsis: Hyperinflammatory Phase vs. Immunoparalysis (CARS)
7. Sepsis-Induced Coagulopathy (SIC) and Disseminated Intravascular Coagulation (DIC)
8. Mitochondrial Dysfunction and "Cellular Hibernation"
9. Procalcitonin (PCT): Biogenesis, Kinetics and Clinical Utility
10. C-Reactive Protein (CRP) and Acute Phase Kinetics
11. Serum Lactate: Hyperlactatemia Type A vs. Type B, Lactate Clearance
12. Complete Blood Count and Derived Indices: Neutrophil/Lymphocyte Ratio and MDW
13. Biomarkers of Acute Kidney Injury Associated with Sepsis (Sepsis-AKI)
14. Biomarkers of Sepsis-Induced Myocardial Dysfunction (SIMD)
15. Biomarkers of Barrier and Glycocalyx Integrity
16. Cellular and Soluble Immune Markers: monocytic HLA-DR, sCD14-ST (Preseptin)
17. Second Wave Cytokines and Additional Acute Phase Proteins (IL-6, IL-8, LBP)
18. Complex Acid-Base Imbalance in Sepsis: Stewart's Physiological Approach
19. Carbohydrate Metabolism: Hyperglycemia from Stress and Insulin Resistance
20. Dyslipidemia and Lipid Metabolism in Sepsis: The role of Lipoproteins (HDL/LDL)
21. Endocrine Dysfunction: Hypothalamus-Pituitary-Adrenal Axis and Sick Euthyroid Syndrome
22. Genomics and Transcriptomics in Sepsis: Identification of Clinical Endotypes
23. Metabolomics and Proteomics Applied to Septic Shock
24. Ultra-Rapid and Molecular Microbiological Diagnosis
25. Advanced Hemodynamic Monitoring and Biochemical Tissue Perfusion
26. Extracorporeal Support: Hemoperfusion with Adsorption Cartridges
27. Directed Immunomodulation: Hydrocortisone, Vitamin C and Thiamine
28. Precision Medicine in Sepsis Oncology and Future Horizons