Palliative Care: Control of Non-Painful Symptoms | Treatise on Palliative Medicine and Continuous Support

Palliative Care · Clinical Specialties

How it begins

Un análisis exhaustivo del manejo paliativo de síntomas no dolorosos en pacientes con enfermedad avanzada, oncológica y no oncológica. Desde la neuroquímica de la disnea y la émesis hasta el control molecular del delirio, la obstrucción intestinal maligna, los trastornos neurovegetativos y la sedación paliativa basada en evidencia clínica.

What it covers

1. Control of Non-Painful Symptoms
2. Dyspnea in the Patient in the Advanced and Terminal Phase
3. · 1.1 · Pathophysiology of Dyspnea: Receptor Circuits and Central Pathways
4. · 1.2 · Pharmacotherapy of Dyspnea: Opioids and Adjuvants
5. · 1.3 · Non-Pharmacological Measures and Physical Approach
6. Premortem Rales and Management of Respiratory Secretions
7. · 2.1 · Pathophysiological Types of Rales
8. · 2.2 · Comparative Anticholinergic Pharmacotherapy
9. · 2.3 · Non-Pharmacological Interventions and Positioning
10. Cough and Hemoptysis in the Palliative Patient
11. · 3.1 · Pathophysiology of the Cough Reflex and Antitussive Therapy
12. · 3.2 · Approach to Mild to Moderate Hemoptysis
13. · 3.3 · Action Protocol for Catastrophic Hemoptysis
14. Emesis Pathophysiology and Key Receptors
15. · 4.1 · The Vomiting Center and the Four Ways of Activation
16. · 4.2 · The Role of the NK1 Receptor in Late Emesis
17. Directed Pharmacological Treatment of Nausea and Vomiting
18. · 5.1 · Antiemetic Drugs and Receptor Affinity Profiles
19. · 5.2 · Antiemetic Rotation and Selection Algorithm
20. Malignant Intestinal Obstruction (MIO) in Cancer Patients
21. · 6.1 · Pathophysiology of the Secret-Exudative Cycle in MIO
22. · 6.2 · Pharmacotherapy of Non-Surgical IOM
23. · 6.3 · Clinical Debate: Nasogastric Decompression Tube vs. Palliative Gastrostomy
24. Constipation/Constipation Associated with Opioids
25. · 7.1 · Pathophysiology of Enteric Opioid Receptors
26. · 7.2 · Pharmacological Management: Classic Laxatives and PAMORAs
27. · 7.3 · Prevention and Support Interventions
28. Anorexia-Neoplastic Cachexia Syndrome (ACS)
29. · 8.1 · Immunology of Cachectizing Metabolic Deviation
30. · 8.2 · Pharmacotherapy of Appetite and Weight Modulation
31. · 8.3 · Ethical Considerations of Artificial Nutrition and Hydration
32. Xerostomia, Sialorrhea and Refractory Hiccups in Advanced Disease
33. · 9.1 · Physiology of Oral Dryness and Sialorrhea
34. · 9.2 · Pathophysiology and Management of Refractory Hiccups
35. Delirium and Terminal Agitation in the Palliative Critically Ill Patient
36. · 10.1 · Neurochemical Pathophysiology of Delirium
37. · 10.2 · Diagnosis and Clinical Screening
38. · 10.3 · Pharmacological Management of Delirium and Terminal Agitation
39. Anxiety, Depression and Insomnia in Palliative Care
40. · 11.1 · Pathophysiology of Anxiety and Insomnia in Palliative Patients
41. · 11.2 · Pharmacotherapeutic Approach to Anxiety and Depression
42. · 11.3 · Insomnia Management Strategies
43. Myoclonus and Opioid-Induced Neurotoxicity (OIN)
44. · 12.1 · Pathophysiology of OIP and Role of the M3G Metabolite
45. · 12.2 · Opioid Rotation as a Rescue Strategy
46. · 12.3 · Seizure Control in the Final Phase
47. Asthenia, Fatigue and Palliative Functional Cachexia
48. · 13.1 · Immunometabolic Pathobiology of Fatigue
49. · 13.2 · Pharmacological Approach and Use of Psychostimulants
50. · 13.3 · Functional Adaptation and Non-Pharmacological Support
51. Pruritus and Profuse Diaphoresis in Palliative Care
52. · 14.1 · Pathophysiology of the Pruritus and Diaphoresis Pathways
53. · 14.2 · Directed Pharmacological Treatment
54. · 14.3 · Physical Measurements and Skin Care
55. Malignant Neoplastic Wounds, Ulcers and Odor Control
56. · 15.1 · Pathobiology of Anaerobic Infections and Odor Control
57. · 15.2 · Control of Exudate and Prevention of Local Bleeding
58. Palliative Sedation and Symptom Control in the Agonizing Phase
59. · 16.1 · Ethical-Legal Differentiation between Palliative Sedation and Euthanasia
60. · 16.2 · Palliative Sedation Induction Algorithm
61. · 16.3 · Management of Second Line Sedatives and Rescue in Agony
62. · 16.4 · Fundamental Principles in the Control of Non-Painful Symptoms