Clinical Epidemiology and Evidence-Based Medicine | Scientific Methodology Treatise

Public Health and Epidemiology · Clinical Bases

How it begins

Tratado comprehensivo sobre los fundamentos lógicos y cuantitativos que rigen la práctica clínica contemporánea. Aborda la construcción de inferencia causal bajo criterios formales, los diseños epidemiológicos analíticos, el tratamiento matemático de sesgos y variables de confusión, el desarrollo analítico de pruebas diagnósticas y modelos de sobrevivencia, la síntesis cuantitativa mediante metanálisis, el marco…

What it covers

1. Clinical Epidemiology and EBM
2. Fundamentals of Clinical Epidemiology and Causal Inference
3. · 1.1 · Epistemology of Causal Inference
4. · 1.2 · Frequency Measurements in Epidemiology
5. · 1.3 · Association and Impact Measures
6. Intervention Studies: Randomized Clinical Trials
7. · 2.1 · The Randomization Process and Bias Control
8. · 2.2 · Analysis Populations: Intention to Treat vs. By Protocol
9. · 2.3 · Complex and Innovative ECA Designs
10. Analytical Observational Studies: Cohorts and Case-Controls
11. · 3.1 · Architecture and Dynamics of Cohort Studies
12. · 3.2 · Architecture of Case and Control Studies
13. · 3.3 · Advanced Methodological Variants
14. Bias, Confusion and Effect Modification
15. · 4.1 · Taxonomy of Epidemiological Biases
16. · 4.2 · Confusion and its Methodological and Analytical Control
17. · 4.3 · Effect Modification (Interaction)
18. Diagnostic Tests: Validity, Safety and Analysis of ROC Curves
19. · 5.1 · Intrinsic Parameters of Diagnostic Validity
20. · 5.2 · Security Parameters: Predictive Values and Bayes' Theorem
21. · 5.3 · Likelihood Ratios
22. · 5.4 · Analysis of ROC Curves (Receiver Operating Characteristic)
23. Prognosis and Survival Studies
24. · 6.1 · Methodological Concept of Censorship
25. · 6.2 · Kaplan-Meier estimator
26. · 6.3 · Cox Proportional Hazards Regression Model
27. Evidence-Based Medicine: Asking Questions and Seeking Information
28. · 7.1 · Epistemological Paradigm and Historical Evolution
29. · 7.2 · Methodical Formulation of Clinical Questions: The PICO Acronym
30. · 7.3 · Systematic Bibliographic Search Strategies
31. Critical Reading of Scientific Literature: International Consortia
32. · 8.1 · Methodological Reporting Guidelines (Reporting Guidelines)
33. · 8.2 · Risk of Bias Assessment Tools
34. Systematic Reviews and Meta-Analyses
35. · 9.1 · Mathematical Data Combination Models
36. · 9.2 · Evaluation of Heterogeneity
37. · 9.3 · Publication Bias and Asymmetry Analysis
38. GRADE Gradation and Preparation of Clinical Practice Guides
39. · 10.1 · The Four Levels of Certainty of Evidence
40. · 10.2 · GRADE Certainty Evaluation Algorithm
41. · 10.3 · Determination of the Strength of the Recommendation
42. Inferential Biostatistics I: Hypothesis Contrast and Parametric Tests
43. · 11.1 · Probability of Error in Inference
44. · 11.2 · Methodical Selection of Statistical Tests
45. Inferential Biostatistics II: Multivariable Regression Models
46. · 12.1 · Multiple Linear Regression Model
47. · 12.2 · Multiple Logistic Regression Model
48. · 12.3 · Diagnostics and Advanced Model Assumptions
49. Pharmacoepidemiology and Phase IV Safety Studies
50. · 13.1 · Justification of post-marketing Pharmacovigilance Studies
51. · 13.2 · Pharmacovigilance Methods and Systems
52. · 13.3 · Active Pharmacovigilance and Inference with Real World Evidence
53. Genomic Epidemiology and Precision Medicine
54. · 14.1 · Genome Whole Association Studies (GWAS)
55. · 14.2 · Mendelian Randomization Methodology
56. Clinical Decision Making and Economic Impact
57. · 15.1 · Decision Tree Models and Markov Models
58. · 15.2 · Health Economic Evaluation Methods
59. · 15.3 · The Incremental Cost-Effectiveness Ratio (ICER)
60. Ethics in Clinical Research, Regulation and Scientific Integrity
61. · 16.1 · Historical Milestones in the Formulation of Medical Bioethics
62. · 16.2 · Main Deviations and Fraudulent Scientific Conduct
63. · 16.3 · Key Methodological Principles in Applied Clinical Epidemiology