Pharmacology: Introduction and General Principles

Pharmacology: Introduction and General Principles — Expert Reference

How it begins

Farmacocinética, farmacodinamia, interacciones y aplicaciones clínicas — un análisis molecular y cuantitativo de cómo los fármacos alcanzan sus dianas, ejercen sus efectos y son eliminados del organismo.

What it covers

1. Definition, Object and Branches of Pharmacology
2. · Brands and Subdisciplines of Pharmacology
3. · Drugs vs. The Medication: Regulatory Aspects
4. Pharmacological Targets: Receptors, Enzymes, Channels and Transporters
5. Pharmacokinetics: ADME Processes
6. · 3.1 Absorption
7. · 3.2 Bioavailability and First Pass Effect
8. · 3.3 Distribution and Distribution Volume (Vd)
9. · 3.4 Binding to Plasma Proteins
10. · 3.5 The Blood-Brain Barrier and Special Compartments
11. Pharmacological Metabolism (Biotransformation)
12. · 4.1 Phase I Reactions (Functionalization)
13. · 4.2 Phase II Reactions (Conjugation)
14. · 4.3 Induction and Enzymatic Inhibition of CYP450
15. Elimination, Clearance and Kinetics
16. · 5.1 Clearance and Elimination Half-Life
17. · 5.2 First Order Kinetics vs. Zero Order Kinetics
18. · 5.3 Steady-State
19. Pharmacodynamics: Mechanisms of Action and Receptors
20. · 6.1 Classification of Pharmacological Receptors
21. · 6.2 GPCRs and Intracellular Signaling Cascades
22. · 6.3 Dose-Response Curves: Efficacy, Potency and Therapeutic Index
23. · 6.4 Agonists, Antagonists, Partial and Inverse Agonists
24. Pharmacokinetics-Pharmacodynamics Integration (PK/PD)
25. · 7.1 Therapeutic Window and Drug Monitoring (TDM)
26. · 7.2 Loading and Maintenance Dose Calculation
27. Drug Interactions: Mechanisms and Clinical Consequences
28. · 8.1 Pharmacokinetic Interactions
29. · 8.2 Pharmacodynamic Interactions
30. Adverse Drug Reactions (ADRs): Classification and Mechanisms
31. · Edwards and Aronson Mechanistic Classification (System A–F)
32. · Drug Hypersensitivity: Gell and Coombs Classification (Adapted)
33. Pharmacokinetics in Special Populations
34. · 10.1 The Child is not a Small Adult: Pediatric Particularities
35. · 10.2 Pharmacology of the Elderly: Polypharmacological Frailty
36. · 10.3 Liver Failure
37. · 10.4 Kidney Failure
38. · 10.5 Pregnancy and Breastfeeding
39. Pharmacogenomics and Precision Medicine
40. · CYP450 Polymorphisms with Established Clinical Relevance
41. · Clinical Implementation: Pharmacogenomics in Practice
42. Chronopharmacology: Time as a Therapeutic Variable
43. · Circadian variations in PK and PD
44. · Clinical Examples of Chronotherapy
45. Glossary of Pharmacokinetic and Pharmacodynamic Terms
46. Select Reference Bibliography
47. · Fundamental Texts
48. · Reference Articles and Reviews