Cancer Genetics

Genetics · Basic Sciences

How it begins

Análisis exhaustivo de la biología molecular del cáncer: desde la transformación maligna y los mecanismos de carcinogénesis hasta las implicaciones diagnósticas, pronósticas y terapéuticas de las alteraciones genómicas en oncología.

What it covers

1. Cancer as a Genetic Disease: Foundational Concepts
2. · Genomic Classification of Cancer Drivers
3. Oncogenes: Activation Mechanisms and Signaling Pathways
4. · Oncogenic Activation Mechanisms
5. · Oncogenes by Functional Category
6. · The RAS-MAPK Pathway: Oncogenic Signaling Paradigm
7. Tumor Suppressor Genes: The Two-Hit Model
8. · Mechanisms of the Second Strike (Loss of Heterozygosity — LOH)
9. · Functional Classification: Gatekeepers vs. Caretakers
10. · Fundamental Oncosuppressants: Molecular Mechanisms
11. Cell Cycle, Checkpoints and their Deregulation in Cancer
12. · Deregulation of CDKs in Cancer
13. Hallmarks of Cancer: The Hallmarks of the Malignant Phenotype
14. Multistage Carcinogenesis: From Normal Tissue to Carcinoma
15. · The Vogelstein Model in Colorectal Cancer
16. · Molecular Pathways of CRC
17. · Clonal Evolution and Intratumoral Heterogeneity
18. Hereditary Predisposition to Cancer Syndromes
19. Somatic Mutations: Drivers, Passengers and the Mutational Landscape of Cancer
20. · Driver vs. Passenger Mutations
21. · Tumor Mutation Burden (TMB) as a Biomarker
22. · Mutational Landscape of the Main Tumors
23. Genomic Instability: CIN, MSI and beyond
24. · Chromosome Instability (CIN)
25. · Microsatellite Instability (MSI)
26. · Nucleotide Instability: Mutations in POLE/POLD1
27. Mutational Signatures: The Trace of the Mutagenic Process
28. Cancer Epigenomics: Alterations beyond the Genetic Code
29. · DNA Methylation in Cancer
30. · Histone Modifications in Cancer
31. · Chromatin Remodeling Regulators (SWI/SNF)
32. Tumor Microenvironment (TME) and Immune Evasion
33. · Immune Evasion: Molecular Mechanisms
34. · Tumor Angiogenesis
35. Molecular Diagnosis of Cancer: from Histology to Genomics
36. · Tumor Molecular Profiling Techniques
37. · Liquid Biopsy: The Tumor Genome in Blood
38. Targeted Oncology Therapy: Exploiting Genomic Vulnerabilities
39. · The Concept of Oncogene Addiction
40. · Synthetic Lethality and other Vulnerabilities
41. Cancer Immunotherapy: Genomic Fundamentals and Biomarkers
42. · Immune Checkpoint Inhibitors (ICIs)
43. · Biomarkers of Response to ICIs
44. · New Immunotherapy Modalities