Genetics: Introduction and General Principles

Genetics · Basic Sciences

How it begins

Una revisión exhaustiva de los fundamentos moleculares de la genética: desde la estructura del ADN y la organización del genoma hasta los mecanismos del flujo de información genética, la replicación, la regulación y las herramientas de análisis molecular.

What it covers

1. History of Genetics: From Peas to Genomics
2. Chemical Structure of DNA: From Nucleotides to the Double Helix
3. · Chemical Composition and Nucleotides
4. · Chargaff Rules and Complementarity of Bases
5. · The Double Helix: Geometry and Conformational Forms
6. · Structure of the Major and Minor Groove: Protein Recognition
7. · DNA Topology and Topoisomerases
8. · Non-Canonical Secondary Structures of DNA
9. Chromatin Organization: From the Nucleosome to the Chromosome Territory
10. · The Nucleosome: Fundamental Unit of Chromatin
11. · Histones: Nucleosomal Proteins and Their Modifications
12. · Chromatin Compaction Levels
13. · Euchromatin vs. Heterochromatin
14. The Human Genome: Organization, Content and Functional Elements
15. · General Data of the Human Genome
16. · Classification of DNA by Function and Structure
17. Eukaryotic Gene Structure: Molecular Anatomy
18. · Cis Regulatory Elements
19. · Alternative Splicing
20. The Central Dogma of Molecular Biology and its Exceptions
21. · Exceptions to the Central Dogma
22. Eukaryotic Transcription: RNA Polymerases and RNA Processing
23. · The Three Eukaryotic Nuclear RNA Polymerases
24. · Mechanism of Transcription by RNA Pol II
25. · Pre-mRNA processing
26. The Genetic Code: Degeneration, Universality and Exceptions
27. · Properties of the Genetic Code
28. · Genetic Code Table (mRNA 5'→3')
29. Translation: Protein Synthesis in the Ribosome
30. · Aminoacyl-tRNA Synthetases: The Code Adapter
31. · Eukaryotic Translation Mechanism
32. DNA Replication: Machinery and Control
33. · Replication and Licensing Origins
34. · The Eukaryotic Replisome
35. · Telomeres and Telomerase
36. Regulation of Gene Expression: Levels and Mechanisms
37. · Transcription Factors: Structural Domains
38. Non-Coding RNA: Genome Regulators
39. Cell Division: Mitosis, Meiosis and the Cell Cycle
40. · The Cellular Cycle: Phases and Checkpoints
41. · Mitosis: Stages and Molecular Machinery
42. · Meiosis: Generation of Genetic Diversity
43. Molecular Analysis Tools: From the Laboratory to the Clinic
44. Functional, Comparative Genomics and Precision Medicine
45. · From the Genome to the Proteome: Omics
46. · Human Genetic Variation and GWAS
47. · Pharmacogenomics: Genetics Applied to Drug Response