Gynecology: Menopause and Climacterium

Gynecology and Obstetrics · Clinical Specialties

How it begins

La transición climatérica representa la reorganización endocrina más profunda de la vida adulta femenina: el agotamiento progresivo de la reserva folicular ovárica desencadena un hipoestrogenismo sostenido con repercusiones vasomotoras, genitourinarias, óseas, cardiovasculares y neuropsiquiátricas que exigen un abordaje individualizado, basado en la evidencia y libre de paradigmas obsoletos.

What it covers

1. · Fundamental Definitions
2. · The STRAW+10 System (Stages of Reproductive Aging Workshop)
3. · Follicular Depletion: The Irreversible Biological Clock
4. · Sequence of Hormonal Changes
5. · The Role of Adipose Tissue and Androgens
6. · Diagnosis is Fundamentally Clinical
7. · Differential Diagnosis of Perimenopausal Amenorrhea
8. · Comprehensive Evaluation in the Climacteric Consultation
9. · Pathophysiology: Dysfunction of KNDy Neurons
10. · Fezolinetant: Diana NK3 as a Non-Hormonal Therapeutic Advance
11. · Stepped Management of Vasomotor Symptoms
12. · Clinical impact of vasomotor symptoms
13. · Physiopathology
14. · Clinical Spectrum
15. · GMS Treatment
16. · The RANK-RANKL-OPG Axis and Accelerated Bone Loss
17. · Diagnosis of Osteoporosis
18. · Therapeutic Strategies
19. · The "Timing Hypothesis"
20. · The Window of Perimenopausal Emotional Vulnerability
21. · Subjective Cognitive Complaints ("Brain Fog")
22. · Sleep Disorders
23. · Fundamental Principle: Need for Progestin with an Intact Uterus
24. · Routes of Administration: Relevance of the First Hepatic Pass
25. · Progestin Regimens
26. · Types of Progestin: Relevance of the Safety Profile
27. · Approved THM Indications
28. · The Women's Health Initiative (WHI): Findings and Reinterpretation
29. · Quantification of Specific Risks
30. · Absolute Contraindications of Systemic MHT
31. · Hypoactive Sexual Desire Disorder (HSDD) and Testosterone Therapy
32. · Comprehensive Approach
33. · Definition and Diagnosis
34. · Etiology
35. · Management: THM is Not Optional
36. · Surgical Menopause: Greater Symptomatic Intensity
37. · Risk Reducing Salpingoophorectomy (RRSO) in BRCA1/2 Carriers
38. · Chemotherapy-Induced Ovarian Failure
39. · Management of Menopause in Survivors of Hormone-Dependent Breast Cancer
40. · Periodic Health Assessment in Postmenopause
41. · Lifestyle Interventions with Greater Evidence Support
42. · Continuous reevaluation of the THM
43. · A comprehensive vision of the health of mature women