Internal Medicine: Rheumatoid Arthritis

Internal Medicine: Rheumatoid Arthritis — Expert Reference

How it begins

Revisión exhaustiva de nivel experto: de la inmunobiología molecular y la genética del riesgo a los algoritmos diagnóstico-terapéuticos más actuales, incluyendo cDMARDs, biológicos, inhibidores de JAK y las estrategias treat-to-target conforme a las guías EULAR 2022.

What it covers

1. Epidemiology and Natural History
2. · Key Epidemiological Characteristics
3. · Natural History without Modifying Treatment
4. Molecular Pathogenesis: The Autoimmune Cascade
5. · 2.1 Genetic Basis of RA
6. · 2.2 Protein Citrulation and ACPAs: The Central Molecular Event
7. · 2.3 Rheumatoid Synovitis: From Beginning to Destruction
8. · 2.4 The Cytokine Microenvironment of RA
9. Clinical Manifestations of RA
10. · 3.1 Joint Commitment
11. · 3.2 Extra-Articular Manifestations
12. ACR/EULAR Classification Criteria 2010
13. Laboratory Diagnosis
14. · 5.1 Rheumatoid Factor (RF)
15. · 5.2 Anti-Citrullinated Protein Antibodies (ACPA) / Anti-CCP
16. · 5.3 Acute and Complete Analytical Phase Reactants
17. Diagnostic Imaging in RA
18. · 6.1 Conventional Radiology
19. · 6.2 Musculoskeletal Ultrasound and Magnetic Resonance
20. Disease Activity Measures
21. · 7.1 DAS28, SDAI and CDAI
22. · 7.2 Definition of Referral Boolean ACR/EULAR 2011
23. Prognostic Factors in RA
24. · Poor Prognostic Factors
25. Treat-to-Target (T2T) Strategy in the AR
26. Conventional DMARDs in RA
27. · 10.1 Methotrexate: The DMARD Anchor of RA
28. · 10.2 Combinations of cDMARDs: The Triple Therapy
29. Biological DMARDs in RA
30. · 11.1 TNF-α Inhibitors: The 5 Drugs
31. · 11.2 IL-6 Receptor Inhibitors: Tocilizumab and Sarilumab
32. · 11.3 Rituximab and Abatacept in RA
33. JAK inhibitors in RA
34. EULAR Therapeutic Algorithm 2022
35. Glucocorticoids in RA: Judicious Use
36. · 15. Biological Level Monitoring (TDM)
37. Cardiovascular Risk in RA
38. Osteoporosis in RA
39. Infections and Vaccination in RA
40. Risk of Neoplasia in RA and its Treatment
41. Rheumatoid Arthritis and Pregnancy
42. Perioperative Management of the Patient with RA
43. · Management of DMARDs in the Perioperative Period
44. · Specific Preoperative Evaluation in RA
45. Emerging Therapies in RA
46. · New Therapeutic Targets in Clinical Research
47. Glossary of Key Terms in AR
48. Select Reference Bibliography
49. · Fundamental Clinical Guidelines
50. · Reference Texts
51. · Seminal Articles and Key Clinical Studies