Osteoarthritis · Internal Medicine

Internal Medicine · Clinical Specialties

How it begins

Artropatía degenerativa progresiva de las articulaciones sinoviales — fisiopatología, diagnóstico y manejo basado en evidencia

What it covers

1. · Osteoarthritis
2. Definition, Epidemiology and Disease Burden
3. · 1.1 Detailed Epidemiology
4. · 1.2 Classification
5. · 1.3 Risk Factors — Detailed Analysis
6. Pathophysiology: A Disease of the Whole Joint
7. · 2.1 Articular Cartilage: Structure and Vulnerability
8. · 2.2 Synovitis: The Inflammatory Component (previously underestimated)
9. · 2.3 Subchondral Bone: Pathological Remodeling
10. · 2.4 Molecular Mediators: Reference Table
11. Pathological Anatomy and Histopathology
12. · 3.1 Sequence of Histological Changes
13. · 3.2 Distinctive Histological Characteristics
14. Clinical Manifestations
15. · 4.1 Cardinal Symptoms
16. · 4.2 OA of Hands
17. · 4.3 Knee OA (Gonarthrosis)
18. · 4.4 Hip OA (Coxarthrosis)
19. · 4.5 Spine OA: Spondylosis and its Complications
20. Diagnosis: Criteria, Laboratory and Images
21. · 5.1 ACR Diagnostic Criteria
22. · 5.2 Laboratory Evaluation
23. · 5.3 Diagnostic Imaging
24. Therapeutic Management: Evidence-Based Guidelines
25. · 6.1 Non-Pharmacological Treatment — Solid Evidence
26. · 6.2 Pharmacological Treatment
27. · 6.3 Intra-articular Treatment
28. · 6.4 Surgical Treatment
29. Erosive / Inflammatory OA — Differentiated Entity
30. · 7.1 Differential Characteristics
31. Differential Diagnosis
32. Current Clinical Practice Guidelines and Emerging Therapies
33. · 9.1 Summary of the Main Guides (2019–2023)
34. · 9.2 Emerging Therapies and DMOADs Pipeline