Pediatrics: Immune System and Allergies

Pediatrics · Clinical Specialties

How it begins

Análisis exhaustivo del desarrollo postnatal del sistema inmune, las inmunodeficiencias primarias, la fisiopatología de las reacciones de hipersensibilidad y el espectro completo de las enfermedades alérgicas en la infancia y adolescencia.

What it covers

1. Introduction: Pediatric Immunological Specificity
2. Postnatal Development of the Immune System
3. · Immunological Ontogeny: from the Fetus to the Adolescent
4. · Immunoglobulins according to Age: Reference Values and Meaning
5. · The Thymus-Periphery Axis: T Lymphocyte Education
6. Innate Immunity in Children: Particularities and Deficits
7. · Physical and Chemical Barriers
8. · Phagocytic Cells: Neutrophils and Macrophages
9. · Complement System
10. · NK Cells (Natural Killer)
11. · PRRs (Pattern Recognition Receptors) and TLRs in Pediatrics
12. Adaptive Immunity: B, T and Immunoglobulin Lymphocytes
13. · B Lymphocytes and Antibody Production
14. · T Lymphocyte Subpopulations: Th1/Th2/Th17/Treg Balance
15. Primary Immunodeficiencies (PID): Diagnosis and Clinical Correlations
16. · 5.1 Predominantly Antibody Defects (Humoral IDPs)
17. · 5.2 Combined Immunodeficiencies (CDI) and Severe Immunodeficiencies (SCDI)
18. · 5.3 Defects of Phagocytosis and the Complement System
19. Hypersensitivity Reactions: Gell and Coombs Classification
20. Pathophysiology of IgE Sensitization and Allergic Reaction
21. · Awareness Phase
22. · Effector Phase: Early and Late Phase Reaction
23. · The Role of Epithelial Alarmins in Allergic Initiation
24. The Atopic March: Natural History of Allergic Disease
25. · Risk Factors of Atopic March
26. Atopic Dermatitis (AD): Pathophysiology, Diagnosis and Treatment
27. · Pathophysiology: The Double Immune-Barrier Defect
28. · Diagnosis: Hanifin and Rajka criteria (modified Williamson)
29. · Morphological Distribution by Age
30. · Severity Assessment
31. · Stepped Treatment (Therapeutic Ladder)
32. Pediatric Allergic Rhinitis
33. · ARIA Classification (Allergic Rhinitis and Its Impact on Asthma)
34. · Diagnosis
35. · Stepped Treatment of Pediatric RA
36. Asthma in Pediatrics: Phenotypes, Diagnosis and Treatment
37. · Phenotypes of Wheezing in Childhood (Martínez Classification)
38. · Asthma Predictive Index (Castro-Rodríguez API)
39. · Diagnosis of Pediatric Asthma
40. · Stepped Treatment of Asthma (GINA 2024 Pediatric)
41. Food Allergy in Pediatrics
42. · Mechanical Classification
43. · Main Food Allergens and Their Natural History
44. · FPIES: Food Protein Induced Enterocolitis Syndrome
45. · Diagnosis of Food Allergy
46. · Oral Tolerance Induction (ITO / OIT)
47. Anaphylaxis in Pediatrics: Recognition and Management
48. · Diagnostic Criteria (WAO / EAACI 2020)
49. · Triggers of Anaphylaxis in Children
50. · Pathophysiology: Biphasic Reaction and Protracted Anaphylaxis
51. Drug Allergy in Pediatrics
52. · Beta-lactam allergy: The most common problem
53. · NSAIDs: Second Cause of Drug Hypersensitivity in Children
54. · Stevens-Johnson Syndrome (SJS) and TEN (Toxic Epidermal Necrolysis)
55. Allergen-Specific Immunotherapy (AIT) in Pediatrics
56. · AIT Action Mechanism
57. · AIT modalities
58. Biological Therapy in Pediatric Allergology