General Principles of Organ Transplantation — General Surgery and Specialties

Surgery · Clinical Specialties

How it begins

Compendio exhaustivo de la biología celular, técnicas de preservación, alorreactividad inmunológica, farmacología inmunosupresora avanzada y abordajes quirúrgicos de la terapéutica sustitutiva de órganos.

What it covers

1. Historical Evolution, Epidemiology and Ethical Frameworks
2. · Epidemiology and the Transplant Gap
3. · International Ethical and Legal Frameworks
4. Transplant Immunology (Allophysiology)
5. · Structure and Expression of HLA Molecules
6. · Allogeneic Recognition Pathways
7. · The T Lymphite Activation Cascade: Three Signals
8. Clinical-Pathological Mechanisms of Rejection
9. · Hyperacute Rejection
10. · Acute Cellular Rejection (TCMR)
11. · Acute Humoral/Antibody-Mediated Rejection (AMR)
12. · Chronic Rejection and Allograft Vasculopathy
13. Compatibility Evaluation and Immunogenetic Typing
14. · HLA Molecular Typing
15. · Calculation of the antibody reactivity panel (cPRA)
16. · Antibody Screening Strategies
17. Brain Death and Pathophysiology of the Cadaveric Donor
18. · Pathophysiology of the Donor in Brain Death
19. · Endocrine-Metabolic Disorders and Hormone Replacement Therapy (HRT)
20. Organ Preservation and Pathophysiology of Ischemia-Reperfusion
21. · Pathophysiology of Cellular Ischemia
22. · The Reperfusion Paradox: Oxygen-Mediated Damage
23. · Physiological Preservation Solutions
24. · Technological Evolution: Machine Perfusion
25. Surgical Principles of Procurement and Implantation
26. · Multiorgan Harvest Surgery (Procura)
27. · Bench Surgery
28. Advanced Pharmacology of Immunosuppression
29. · Immune Induction Therapy
30. · Maintenance Therapy: The Triple Standard Scheme
31. Chronology of Opportunistic Infections and Systemic Complications
32. · Post-Transplant Lymphoproliferative Disorders (PTLD)
33. Surgical and Clinical Particularities by Solid Organ
34. · 1. Kidney Transplant
35. · 2. Liver Transplant
36. · 3. Heart Transplant
37. · 4. Lung Transplant
38. Xenotransplantation, Immunological Tolerance and the Future of Transplant Surgery
39. · Precision Xenotransplantation: Gene Editing of Porcine Platforms
40. · Induction of Immunological Tolerance and Mixed Chimerism