Immune Response and Tolerance — Immunology

Immunology · Basic Sciences

How it begins

El sistema inmune es la red integrada de células, tejidos y moléculas que defiende al organismo frente a agentes infecciosos, células tumorales y otras amenazas, manteniendo simultáneamente la tolerancia hacia los propios tejidos. Su misión fundamental es distinguir entre lo propio ( self ) y lo extraño ( non-self ), respondiendo a lo segundo con precisión y proporcionalidad.

What it covers

1. Respuesta Inmune y Tolerancia
2. The Immune System — Overview
3. · The Two Arms of the Immune System
4. · Fundamental Properties of the Adaptive Immune Response
5. Immune System Cells
6. Lymphoid Organs
7. · Lymphatic Node Architecture
8. Innate Immunity
9. · Pattern Recognition Receivers (PRR)
10. · The Inflammasome — IL-1β Processing Machine
11. · Complement System
12. · NK Cells — Natural Killers
13. Antigens and Antigenic Presentation
14. · Major Histocompatibility Complex (MHC) / HLA
15. · Dendritic Cells — The Innate-Adaptive Bridge
16. T lymphocytes
17. · T Lymphocyte Maturation in the Thymus
18. · CD4⁺ T Helper lymphocytes
19. · CD8⁺ Cytotoxic T lymphocytes (CTL)
20. · Regulatory T lymphocytes (Treg)
21. B Lymphocytes and Antibodies
22. · Immunoglobulins — Structure and Function
23. · The T-Dependent Response and the Germinal Center
24. Cytokines and Immune Signaling
25. · JAK/STAT Pathway — Cytokine Signaling
26. Immunological Tolerance
27. · Central Tolerance
28. · Peripheral Tolerance
29. · Immune Checkpoints — Self Tolerance in the Tumor Context
30. Hypersensitivity
31. Autoimmunity — When Tolerance Fails
32. · Predisposing Factors
33. · Autoimmune Diseases — Classification and Mechanisms
34. Immunodeficiencies
35. · Primary Immunodeficiencies (PID) — By Affected Component
36. · Secondary Immunodeficiency — HIV/AIDS
37. Antitumor Immunity
38. · The Immunoediting Model — The 3 Es
39. · Immunotherapy — Tools to Restore Antitumor Immunity
40. Integration and Final Perspective
41. · The Great Immunological Connections
42. · Final Summary
43. · Bibliographical References