EpistemisInteractive Lupus Activity Calculator (SLEDAI-2K Simplified)
Select all the clinical and immunological manifestations observed to be active in the last 10 days:
Required inputs
| Variable | Example value |
|---|---|
| Severe Neurological Compromise (8 points): New onset seizures, active psychosis or acute organic brain syndrome. | 8 |
| Active vasculitis (8 points): Ischemic digital skin ulcers, periungual infarcts or gangrene. | 8 |
| Inflammatory Arthritis (4 points): Objectable clinical synovitis in ≥ 2 joints. | 4 |
| Myositis (4 points): Proximal muscle weakness associated with elevated CPK or aldolases. | 4 |
| Renal Alteration / Casts (4 points): Granular casts, erythrocytes or new-onset proteinuria > 0.5 g/24h. | 4 |
| Active Cutaneous Manifestations (2 points): Diffuse alopecia or new-onset inflammatory malar erythema. | 2 |
| Serositis (2 points): Clinically manifest pleuritis or pericarditis with classic rubbing or pain. | 2 |
| Hypocomplementemia (2 points): Active analytical consumption of serum C3 or C4. | 2 |
| Elevated anti-dsDNA (2 points): Persistent increase above the reference limit value. | 2 |
| Unexplained fever (1 point): Persistent rectal or axillary temperature > 38°C. | 1 |
| Thrombocytopenia (1 point): Acute platelet count | 1 |
| Leukopenia (1 point): Total leukocyte count | 1 |
Run the calculation in the app
This page explains the score but does not run it. In Epistemis, the calculator validates units, flags values outside physiological ranges, and provides the interpretation that a number alone cannot convey.
Epistemis is educational review material. It is not a medical device, does not diagnose or prescribe treatment, and does not replace formal medical training, current clinical guidelines, or professional clinical judgment.
- Specialty
- Rheumatology
- Area
- Internal Medicine
- Variables
- 12