EpistemisEULAR/ACR 2019 Classification Criteria for Systemic Lupus Erythematosus
For each domain, select only the finding with the highest score present in the patient:
Required inputs
| Variable | Example value |
|---|---|
| Do you meet Entry Criteria? ANA Title ≥ 1:80 (Mandatory). | — |
| Unexplained fever (> 38°C) (2 points) | 2 |
| None / Not applicable | 0 |
| Proven autoimmune hemolytic anemia (4 points) | 4 |
| Acute thrombocytopenia ( (3 points) | 3 |
| Leukopenia ( (3 points) | 3 |
| None / Not applicable | 0 |
| Convulsive state of illness or acute convulsions (5 points) | 5 |
| Lupus psychosis (3 points) | 3 |
| Acute lupus delirium (2 points) | 2 |
| None / Not applicable | 0 |
| Acute cutaneous lupus (malar erythema, bullous lupus) (6 points) | 6 |
| Subacute cutaneous lupus or chronic discoid lupus (4 points) | 4 |
| Idiopathic oral or nasal ulcers (2 points) | 2 |
| Diffuse non-scarring alopecia (2 points) | 2 |
| None / Not applicable | 0 |
| Acute pericardial effusion or proven pericarditis (6 points) | 6 |
| Pleural effusion or acute bilateral pleuritis (5 points) | 5 |
| None / Not applicable | 0 |
| Inflammatory arthritis (Jaccoud arthropathy or synovitis of at least 2 joints with prolonged morning stiffness) (6 points) | 6 |
| None / Not applicable | 0 |
| Renal biopsy confirmatory of Lupus Nephritis Class III or IV (10 points) | 10 |
| Renal biopsy confirmatory of Lupus Nephritis Class II or V (8 points) | 8 |
| Clinically significant proteinuria (> 0.5 g/24 hours) (4 points) | 4 |
| None / Not applicable | 0 |
| Lupus anticoagulant, anti-cardiolipin IgG/IgM or anti-beta2GPI IgG/IgM positive (2 points) | 2 |
| None / Not applicable | 0 |
| Combined consumption of decreased C3 AND decreased C4 (4 points) | 4 |
| Isolated decrease in decreased C3 OR decreased C4 (3 points) | 3 |
| None / Not applicable | 0 |
| Positive anti-dsDNA AND/OR positive anti-Smith antibodies (6 points) | 6 |
| None / Not applicable | 0 |
Run the calculation in the app
This page explains the score but does not run it. In Epistemis, the calculator validates units, flags values outside physiological ranges, and provides the interpretation that a number alone cannot convey.
Epistemis is educational review material. It is not a medical device, does not diagnose or prescribe treatment, and does not replace formal medical training, current clinical guidelines, or professional clinical judgment.
- Specialty
- Rheumatology
- Area
- Internal Medicine
- Variables
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