Molecular Biology — Introduction and General Principles

Molecular Biology · Basic Sciences

How it begins

Estudio exhaustivo de los fundamentos de la biología molecular: estructura química de los ácidos nucleicos, dogma central, replicación, transcripción, traducción, regulación génica y correlaciones con la patología molecular humana.

What it covers

1. History, Definition and Scope of Molecular Biology
2. · 1.1 Founding Historical Milestones
3. · 1.2 Definition and Object of Study
4. Nucleic Acids: DNA and RNA
5. · 2.1 Nucleotides: The Structural Units
6. · 2.2 Structure of DNA
7. · 2.3 Structure of RNA
8. The Central Dogma of Molecular Biology
9. · 3.1 Original Formulation and Extension
10. · 3.2 Implications of the Central Dogma
11. Chromatin: DNA Packaging and Epigenetics
12. · 4.1 DNA Packaging Levels
13. · 4.2 Histones: Structure and Variants
14. · 4.3 Histone Modifications and Histone Code
15. · 4.4 DNA Methylation: The Canonical Epigenetic Mark
16. DNA Replication
17. · 5.1 General Principles
18. · 5.2 Replication Enzymes and Proteins
19. · 5.3 Replication Fidelity
20. RNA Transcription and Maturation
21. · 6.1 Eukaryotic RNA Polymerases
22. · 6.2 Structure of Eukaryotic Promoters (RNA Pol II)
23. · 6.3 Preinitiation and Elongation Complex
24. · 6.4 Pre-mRNA Processing (Splicing and Co- and Post-transcriptional Modifications)
25. Genetic Code and Translation
26. · 7.1 The Genetic Code
27. · 7.2 Ribosomes
28. · 7.3 Eukaryotic Translation Mechanism
29. Mutations: Types, Mechanisms and Consequences
30. · 8.1 Classification of Mutations
31. · 8.2 Mutagenic Agents
32. DNA Repair Mechanisms
33. · 9.1 Overview
34. Regulation of Gene Expression
35. · 10.1 Regulation in Prokaryotes: The Operon
36. · 10.2 Regulation in Eukaryotes
37. Integrative Clinical Correlations
38. · 11.1 Molecular Biology Tools in Diagnostics
39. · 11.2 Molecular Oncology: The Hallmarks of Cancer and its Molecular Basis
40. · 11.3 Next Generation Gene Therapies and RNA