Central Dogma of Molecular Biology

Molecular Biology · Basic Sciences

How it begins

En 1958, Francis Crick enunció lo que denominó el "Dogma Central de la Biología Molecular" , una declaración que define la dirección del flujo de información genética en los sistemas biológicos. Contrariamente a lo que el término "dogma" podría sugerir, Crick lo utilizó con consciencia irónica; sin embargo, el concepto ha resistido más de seis décadas de escrutinio experimental y representa uno de los principios…

What it covers

1. The Central Dogma of Molecular Biology
2. · History and Scientific Context
3. DNA Structure and Organization
4. · Primary Structure: The Double Helix
5. · Complementarity of Bases: The Chargaff Principle
6. · DNA conformations: A, B and Z
7. · Chromatin Organization in Eukaryotes
8. DNA Replication
9. · Enzymatic Replication Machinery
10. · DNA Fidelity and Repair
11. Transcription: DNA → RNA
12. · RNA Polymerases
13. · Stages of Transcription
14. · Pre-mRNA Processing in Eukaryotes
15. · Types of RNA and their Functions
16. Translation: RNA → Protein
17. · The Genetic Code
18. · tRNA and Aminoacyl-tRNA Synthetases
19. · Ribosome Structure
20. · Stages of Translation in Eukaryotes
21. · Post-translational Modifications (PTMs)
22. The Central Dogma Extended
23. · Reverse Transcriptase: Mechanism and Pharmacology
24. · RdRp Viral: Viral RNA Replication and Antivirals
25. Gene Regulation and Epigenetics
26. · Transcriptional Regulation: Transcription Factors
27. · Epigenetics: Information Beyond the DNA Sequence
28. · Non-Coding RNA as Regulators
29. Mutations and Genetic Disease
30. Antibiotics and the Central Dogma
31. · Inhibitors of Bacterial DNA Replication
32. · Bacterial Transcription Inhibitors
33. · Inhibitors of Bacterial Protein Synthesis
34. Molecular Oncology: The Disturbed Dogma
35. · Oncogenes and Tumor Suppressor Genes
36. · The Master Oncogene: MYC
37. · Post-transcriptional and Translational Regulation in Cancer
38. Molecular Virology: The Hacked Dogma
39. Modern Molecular Therapeutics
40. · Gene Therapy: Correction at the DNA Level
41. · Gene Editing: CRISPR-Cas9
42. · RNA-Based Therapies