Cell Cycle and Cancer — Molecular Biology

Molecular Biology · Basic Sciences

How it begins

Análisis exhaustivo y técnicamente riguroso de la regulación del ciclo celular, las bases moleculares de la transformación neoplásica, las vías de señalización oncogénicas, el microambiente tumoral y las dianas terapéuticas en oncología de precisión.

What it covers

1. Introduction: The Cell Cycle as the Axis of Molecular Oncology
2. Phases of the Cell Cycle: Temporal Organization
3. · Division of the cycle into phases
4. CDKs, Cyclins and Inhibitors: The Molecular Engine of the Cycle
5. · Cyclin-dependent kinases (CDKs)
6. · CDK inhibitors (CKIs)
7. Cell Cycle Checkpoints (Checkpoints)
8. · Concept and function of checkpoints
9. The Rb–E2F Pathway: The G1/S Restriction Point
10. · The Rb protein as a master regulator of G1/S
11. p53 — The Guardian of the Genome
12. · Structure and function of p53
13. · P53 regulation: the MDM2–p53 axis
14. Apoptosis: Programmed Cell Death and its Regulation in the Cell Cycle
15. · Apoptosis pathways
16. Cellular Senescence, Quiescence and Mitotic Catastrophe
17. · Senescence as a tumor barrier
18. Cancer Hallmarks — Hanahan Weinberg
19. Oncogenes and Proto-oncogenes
20. · Oncogenic activation mechanisms
21. · Oncogenes of greatest clinical relevance
22. Tumor Suppressor Genes
23. · Classification and inactivation mechanisms
24. Genomic Instability and DNA Repair Pathways in Cancer
25. · The genome as a constant target of damage
26. Epigenetics and Cancer
27. · Epigenetic alterations in neoplastic transformation
28. Panorama of Signaling Pathways in Cancer
29. RAS–MAPK Pathway: Oncogenic Mitogenic Signaling
30. · Molecular cascade of the RAS–MAPK pathway
31. PI3K–AKT–mTOR Pathway: Survival, Metabolism and Growth
32. · The central survival path
33. Wnt–β-catenin Pathway and Colorectal Cancer
34. · Regulation of β-catenin
35. Notch and Hedgehog tracks
36. · Notch
37. · Hedgehog (Hh)
38. TGF-β Pathway: From Suppressor to Metastasis Promoter
39. Tumor Angiogenesis: the Angiogenic Switch
40. · The angiogenic switch
41. Invasion, Metastasis and Epithelial-Mesenchymal Transition (EMT)
42. · The metastatic cascade
43. · Epithelial-Mesenchymal Transition (EMT)
44. Tumor Microenvironment (TME)
45. · Composition and function of the TME
46. Tumor Immunoediting and Immune Escape
47. · The three E's: Elimination, Balance and Escape
48. Telomeres, Telomerase and Replicative Immortality
49. · Telomere biology
50. · Reactivation of telomerase in cancer
51. Molecular Targeted Therapy in Oncology
52. · Principles of targeted therapy
53. Cellular Immunotherapy: CAR-T, TILs and TCR-T
54. · CAR-T cells
55. Mechanisms of Resistance to Antineoplastic Therapy
56. · Intrinsic and acquired resistance
57. Precision Medicine in Oncology: Present and Future
58. · From histological diagnosis to molecular diagnosis
59. · Basket, umbrella and adaptive essays
60. · Future perspectives