Clinical Biochemistry — Cancer and Molecular Pathology

Biochemistry · Basic Sciences

How it begins

Un compendio exhaustivo y de nivel de especialización médica sobre las bases moleculares del cáncer. Aborda la señalización oncogénica, el remodelado metabólico e inmunológico, la caracterización avanzada de biomarcadores séricos y genéticos, y los retos analíticos en el laboratorio clínico.

What it covers

1. Introduction to Oncological Biochemistry and Hallmarks
2. · The Hallmarks of Cancer and its Molecular Mediators
3. · Main Oncological Signal Transduction Pathways
4. Tumor Metabolism and the Warburg Effect
5. · Comparison of the Performance and Flow of Metabolic Carbons
6. · Enzymatic Mechanisms of Aerobic Glycolysis
7. · Glutaminolysis: The alternative nitrogen fuel
8. Classical Serum and Tissue Biomarkers
9. · Detailed Biochemical Analysis of Classic Tumor Biomarkers
10. Precision Genetic and Epigenetic Markers
11. · Main Genomic Alterations and Their Therapeutic Implication
12. · Tumor Mutational Burden (TMB): The Neoantigen Metric
13. Clinical Oncology Enzymology
14. · Main Enzymes of Clinical Use in Oncology
15. Oncological Proteomics and Metabolomics
16. Biochemistry of Invasion and Metastasis
17. · The Cascade of Invasion and Metastasis
18. Tumor Immunology and Microenvironment
19. · Biochemistry of Immune Checkpoints
20. · The Immunosuppressive Tumor Microenvironment (ITM)
21. Paraneoplastic Endocrine-Metabolic Syndromes
22. · Main Endocrinopathies and Paraneoplastic Alterations
23. Pharmacogenomics and Therapeutic Resistance
24. · Genetic Variants and their Clinical Impact on Oncological Treatment
25. Hydroelectrolyte Alterations and Tumor Lysis Syndrome
26. · Pathophysiology of Tumor Lysis Syndrome (TLS)
27. Advanced Liquid Biopsy and cfDNA
28. Analytical Phase, Interferences and Quality Control
29. · Main Analytical Challenges and Interferences
30. Clinical Cases and Laboratory Correlations