Clinical Biochemistry: Breast Cancer - Reference Treatise on Molecular Oncology

Biochemistry · Basic Sciences

How it begins

Exploración sistemática y exhaustiva de la patología oncológica mamaria: vías de transducción de señales, heterogeneidad molecular, reprogramación metabólica, microambiente tumoral, inmunoensayos de biomarcadores, firmas transcriptómicas de expresión génica, biopsia líquida y bases moleculares de la resistencia terapéutica.

What it covers

1. · Domain Structure and Regulation of the Estrogen Receptor Alpha (ERα)
2. · The ErbB/HER Receptor Signaling Pathway
3. · DNA Repair and Biology of the BRCA1 and BRCA2 Genes
4. · The Regulation of the Cell Cycle in Breast Cancer
5. · Peris-Sørlie Intrinsic Classification
6. · Analytical Quantification by Immunohistochemistry (IHC)
7. · The Warburg Effect (Aerobic Glycolysis)
8. · Lipid Metabolism and Glutaminolysis
9. · The Tumor Antigen CA 15-3 and the MUC1 Gene
10. · Kinetics of Elimination, Purification and False Positives
11. · Oncotype DX Multigenic Assay (Recurrence Score)
12. · Alternative Transcriptomic Signatures
13. · Circulating Free DNA (cfDNA) and Circulating Tumor DNA (ctDNA)
14. · Circulating Tumor Cells (CTCs)
15. · Matrix Remodeling and Cancer Associated Fibroblasts (CAFs)
16. · Immune Escape and PD-1 / PD-L1 Pathway
17. · Resistance to Endocrine Therapy
18. · Resistance to Targeted Anti-HER2 Therapy and Chemotherapy
19. · CDK4/6 and PARP inhibitors
20. · Antibody-Drug Conjugates (ADCs)