Clinical Biochemistry of Thyroid Function — Expert Treatise

Biochemistry · Basic Sciences

How it begins

Análisis ultra-estructural de la síntesis, transporte, regulación y diagnóstico de laboratorio de las hormonas tiroideas con sus correlaciones patológicas

What it covers

1. Introduction and Embryology of the Thyroid Axis
2. Histophysiology of the Thyroid Gland
3. · 1.1 Thyrocyte Cellular Polarity
4. · 1.2 The Thyroid Colloid
5. · 1.3 Parafollicular Cells (C Cells)
6. Molecular Biosynthesis of Thyroid Hormones
7. · 2.1 Expression and Glycosylation of Thyroglobulin (Tg)
8. · 2.2 Active Iodide Uptake ($I^-$) — The NIS Sinporter
9. · 2.3 Apical Efflux of Iodide into the Colloid — Pendrine
10. · 2.4 Activation and Generation of Hydrogen Peroxide ($H_2O_2$)
11. · 2.5 Oxidation of Iodide
12. · 2.6 Iodination of Tyrosine Residues (Iodine Organization)
13. · 2.7 Oxidative Coupling Reaction (Generation of $T_4$ and $T_3$)
14. · 2.8 Thyroglobulin Endocytosis and Lysosomal Proteolysis
15. Peripheral Transport of Thyroid Hormones
16. · 3.1 Main Plasma Transport Proteins
17. · 3.2 The Free Hormone Hypothesis
18. Peripheral Metabolism and Deiodination
19. · 4.1 Comparative Enzymology of Deiodinases
20. · 4.2 Alternative Metabolic Purification Pathways
21. Cellular Action Mechanism and Nuclear Receptors
22. · 5.1 Genetics and Structure of TR Receptors
23. · 5.2 Biochemistry of the Transcriptional Complex
24. · 5.3 Non-Genomic Actions of Thyroid Hormones
25. Homeostatic Regulation of the Hypothalamus-Pituitary-Thyroid Axis
26. · 6.1 Thyrotropin Releasing Hormone (TRH)
27. · 6.2 Thyrotropin (Thyroid Stimulating Hormone / TSH)
28. · 6.3 Cellular Signaling of the TSH Receptor (TSHR)
29. · 6.4 Negative Feedback Mechanisms (Feedback)
30. Laboratory Diagnosis and Biochemical Tests
31. · 7.1 TSH Quantification by Immunometric Assays (Sandwich)
32. · 7.2 Quantification of FT₄ and FT₃ by Competitive Immunoassays
33. · 7.3 Autoantibodies of Diagnostic Relevance
34. · 7.4 The Hook Effect (Prozone Hook Effect) in Immunoassays
35. Pathophysiology and Highly Complex Clinical Correlations
36. · 8.1 Chronic Autoimmune Thyroiditis (Hashimoto's Thyroiditis)
37. · 8.2 Graves-Basedow Disease
38. · 8.3 Amiodarone-Induced Thyroid Dysfunction Syndromes (AIT)
39. · 8.4 Allan-Herndon-Dudley Syndrome
40. · 8.5 Integrated Table of Complex Thyroid Biochemical Profiles
41. · 8.6 Thyroid Dysfunction and Coexisting Adrenal Insufficiency (Schmidt Syndrome)
42. · Integrating Principle of Thyroid Biochemistry