Clinical Biochemistry — Glucocorticoids

Biochemistry · Basic Sciences

How it begins

Tratado exhaustivo y de nivel experto sobre la bioquímica de los glucocorticoides. Desde la esteroidogénesis mitocondrial profunda y la dinámica molecular del receptor NR3C1 hasta los protocolos analíticos avanzados y la interpretación clínica diferencial de la patología suprarrenal.

What it covers

1. Chemical Structure and Biosynthesis in the Adrenal Cortex
2. Regulation of the Hypothalamus-Pituitary-Adrenal Axis (HPA)
3. · Neuroendocrine cascade mechanism
4. The Glucocorticoid Receptor (GR/NR3C1)
5. · Molecular biology of the receptor
6. Genomic Mechanisms: Transactivation and Transrepression
7. Fast Non-Genomic Pathways
8. Physiological and Metabolic Actions: Hydrocarbon Metabolism
9. Protein and Lipid Metabolism
10. · Deep protein catabolism
11. · Lipid metabolism with bimodal distribution
12. Hydroelectrolyte Balance and Cardiovascular Effects
13. · Vascular sensitization and pressor tone
14. · Effects on renal sodium and water transport
15. Effects on Bone and Connective Tissue
16. · Glucocorticoid-induced osteoporosis (GIOP)
17. Immune and Inflammatory Regulation: Deep Immunosuppression
18. Laboratory Analytical Phase: Cortisol Transport
19. · Molecular distribution in serum
20. Analytical Methods for Cortisol Determination
21. Functional Dynamic Tests of the HPA Axis
22. Pathology of Excess: Cushing's Syndrome
23. · Physiopathological classification
24. Analytical Pathophysiology and Biochemical Alterations in Cushing
25. Hypercortisolism Diagnostic Algorithm
26. Default Pathology: Primary Adrenal Insufficiency
27. · Addison's disease: Destruction of the adrenal cortex
28. Secondary and Tertiary Adrenal Insufficiency
29. · Central defects of the HPA axis
30. Acute Adrenal Crisis and Emergency Protocol in the Laboratory
31. Congenital Adrenal Hyperplasia (CAH)
32. · Biosynthesis defect with compensatory stimulation
33. Diagnostic Steroid Profiles in HSC
34. Clinical Pharmacology of Synthetic Glucocorticoids
35. · Chemical structural modifications
36. Mechanisms of Resistance to Glucocorticoids
37. Clinical Cases and Interpretation of Biochemical Profiles