Clinical Biochemistry of Demyelinating Diseases

Clinical Biochemistry of Demyelinating Diseases — Expert Atlas

How it begins

Estudio exhaustivo de la ultraestructura de la mielina, metabolismo lipídico, inmunopatología de la barrera hematoencefálica y biomarcadores analíticos de alta sensibilidad en el líquido cefalorraquídeo

What it covers

1. Biogenesis and Dynamic Structure of Myelin
2. The Molecular Architecture of Myelin
3. · 1.1 Protein Composition of CNS Myelin
4. · 1.2 The Myelin Lipidome and its Role in Compaction
5. Biochemical Pathophysiology of Demyelination
6. · 2.1 Disruption of the Blood-Brain Barrier (BBB)
7. · 2.2 Glutamate Excitotoxicity and Oligodendrocyte Damage
8. · 2.3 Oxidative Stress and Mitochondrial Injury in Myelin
9. Multiple Sclerosis (MS) — The Demyelinating Paradigm
10. · 3.1 Cellular Immunopathology: The Th1/Th17 Axis and B Cells
11. · 3.2 Intrathecal Compartment and Oligoclonal Bands (BOC)
12. · 3.3 New Biochemical Biomarkers in Multiple Sclerosis
13. NMOSD and MOGAD: Non-Classic Autoimmune Demyelination
14. · 4.1 Neuromyelitis Optica Spectrum (NMOSD) and Ac. Anti-Aquaporin 4
15. · 4.2 Myelin Oligodendrocyte Glycoprotein Antibody Disease (MOGAD)
16. Leukodystrophies: Inborn Errors of Myelin Metabolism
17. · 5.1 X-Linked Adrenoleukodystrophy (X-ALD): Peroxisomal Dysfunction
18. · 5.2 Metachromatic Leukodystrophy (MLD): Accumulation of Sulfatides
19. · 5.3 Krabbe Disease (Globoid Cell Leukodystrophy): Psychosin Toxicity
20. Other Acquired and Infectious Demyelinating Pathologies
21. · 6.1 Acute Disseminated Encephalomyelitis (ADEM)
22. · 6.2 Progressive Multifocal Leukoencephalopathy (PML): Oligodendrocyte Infection
23. · 6.3 Osmotic Demyelination Syndrome (Central Pontine Myelinolysis)
24. Advanced Analytical Biochemistry and Biomarkers in the Clinical Laboratory
25. · 7.1 High Sensitivity Analytical Methodologies
26. · 7.2 Summary of Biochemical Diagnostic Profiles
27. · Final Integrating Principle