Clinical Biochemistry: Epigenetics and Disease - Pathological Reference Treatise

Biochemistry · Basic Sciences

How it begins

Dinámica estructural de la cromatina, metilación del ADN y metabolismo de un solo carbono, modificaciones postraducionales de las histonas, regulación por ARNs no codificantes y la traslación clínica en oncología, cardiología, neurología y terapéutica avanzada.

What it covers

1. · The Repetitive Unit: The Nucleosome and its Ultrastructure
2. · The Fundamental Chemical Reaction
3. · Metabolic Intersection: The Single Carbon Cycle and SAM Synthesis
4. · The "Histone Code" Hypothesis
5. · MicroRNAs (miRNAs): Biogenesis and Post-Transcriptional Silencing
6. · Neoplastic Epigenetic Duality
7. · Barker's Hypothesis: Fetal Programming of Adult Illness
8. · Neurodevelopmental Diseases and Loss of Imprinting
9. · Epigenetics of Systemic Lupus Erythematosus (SLE)
10. · Infectious Latency of the Human Immunodeficiency Virus (HIV-1)
11. · The Revolution of Cell-Free Circulating DNA (cfDNA)
12. · DNA Methyltransferase Inhibitors (DNMT Inhibitors / Hypomethylating Agents)