Clinical Biochemistry of Cellular Aging | Molecular Gerontology Treatise

Biochemistry · Basic Sciences

How it begins

Estudio en profundidad de los mecanismos moleculares del envejecimiento, integrando inestabilidad genómica, biología de telómeros, estrés oxidativo, colapso de la proteoestasis, epigenética y remodelación de la matriz extracelular, con sus correspondientes correlaciones de diagnóstico clínico y dianas terapéuticas emergentes.

What it covers

1. Cellular Aging
2. The Senescent Phenotype and Genomic Instability
3. · 1.1 · Genomic Stressors and the DNA Damage Response (DDR)
4. · 1.2 · Types of DNA Damage and Specific Repair Pathways
5. · 1.3 · Systemic Consequences of Genomic Instability
6. Telomere Biology and the Shelterina Complex
7. · 2.1 · Structure of Telomeres and the Shelterina Protective Complex
8. · 2.2 · Biochemistry of Telomerase and Ribonucleoprotein Structure
9. · 2.3 · The G-Quadruplex Transition Phenomenon
10. Signaling Pathways for the Stop of the Cellular Cycle
11. · 3.1 · The p53-p21 CIP1 Axis: G1/S Transition Control
12. · 3.2 · Formation of Senescence-Associated Heterochromatin Foci (SAHF)
13. Oxidative Stress and Mitochondrial Insufficiency (Mito-Aging)
14. · 4.1 · Dynamics of Electron Leakage and Production of Free Radicals
15. · 4.2 · Mitochondrial DNA (mtDNA) vulnerability
16. Proteostasis Collapse and Loss of Proteolysis
17. · 5.1 · The Ubiquitin-Proteasome System (UPS) in Aging
18. · 5.2 · Accumulation of Lipofuscin and Advanced Glycation Products (AGEs)
19. The Senescence-Associated Secretory Phenotype (SASP)
20. · 6.1 · Biochemical Architecture of the SASP Components
21. Epigenetic Alterations and Horvath's Clocks
22. · 7.1 · DNA Methylation and Architectural Changes
23. · 7.2 · Biostatistics of Epigenetic Aging Clocks
24. Sensory Nutrient Dysregulation
25. · 8.1 · The Anabolic Nutritional Axis: IIS Signaling and mTOR Complex
26. · 8.2 · The Catabolic Axis of Longevity: AMPK and Sirtuins (NAD + Axis)
27. Stem Cell Exhaustion
28. · 9.1 · Alterations in Key Tissue Niches
29. · 9.2 · Dynamics of Asymmetric Self-Renewal Loss
30. Transposons and the cGAS-STING Pathway
31. · 10.1 · Derepression of Transposons and LINE-1 Elements
32. Lipid Metabolism and Cell Membranes
33. · 11.1 · Biochemistry of Membrane Lipid Peroxidation
34. · 11.2 · Imbalance in the Composition of Lipid Rafts
35. Biochemistry of Extracellular and Interstitial Aging
36. · 12.1 · Collagen Glycation and Maillard Cross-Link Formation
37. · 12.2 · Imbalance in the Activity of Metalloproteinases (MMPs)
38. Immunosenescence and the Inflammaging Phenomenon
39. · 13.1 · Thymic Involution and Remodeling of the T Lymphocyte Repertoire
40. · 13.2 · The Dual Role of Macrophages in Peripheral Senescence
41. Biomarkers of Senescence and Diagnosis
42. · 14.1 · Kinetics and Histochemistry of Senescence-Associated β-Galactosidase (SA-β-gal)
43. · 14.2 · Molecular Markers for Immunohistochemistry and Protein Profiling
44. Accelerated Aging Syndromes
45. · 15.1 · Hutchinson-Gilford Syndrome: The Defect in Nuclear Lamination
46. · 15.2 · Molecular Physiopathology of Werner, Cockayne and Ataxia-Telangiectasia
47. Senolithic and Senomorphic Strategies
48. · 16.1 · Mechanisms of Action of Senolytic Drugs
49. · 16.2 · Pharmacology of Senomorphic Agents
50. · 16.3 · Key Principles in Clinical Biochemistry of Cellular Aging