Clinical Biochemistry: Protein Degradation Systems

Biochemistry · Basic Sciences

How it begins

Estudio bioquímico y patológico del aclaramiento proteico intracelular: el sistema ubicuitina-proteasoma, la vía autofágico-lisosómica, chaperonas, mecanismos de ERAD y sus profundas implicaciones clínicas.

What it covers

1. Proteostasis and Degradation Kinetics
2. · Kinetics of Protein Degradation
3. The Ubiquitin-Proteasome System (UPS)
4. · The Ubiquitin Molecule and the Ubiquitination Code
5. · The Enzymatic Ubiquitination Cascade
6. · Deubiquitinating Enzymes (DUBs): The Code Editors
7. Structure and Function of the 26S Proteasome
8. · The Central Particle 20S (Core Particle, CP)
9. · The Regulatory Particle 19S (PA700)
10. The Lysosomal Pathway and Autophagy
11. · Molecular Classification of Autophagy
12. · The Molecular Machinery of Macroautophagy
13. · Chaperone-Mediated Autophagy (CMA): Lysosomal Specificity
14. Other Intracellular Proteolytic Pathways
15. · The Calpain System
16. · The Caspasas Waterfall
17. · Cytosolic Oligopeptidases
18. Endoplasmic Reticulum Associated Degradation (ERAD)
19. Physiological Regulation of Protein Degradation
20. · The mTORC1 Signaling Pathway and Nutrient Sensing
21. · Endocrine Control of Protein Catabolism
22. Pathology I: Neurodegenerative Diseases
23. Pathology II: Oncology and Drug Therapy
24. · Addiction of Multiple Myeloma Cells to the Proteasome
25. · The Technology of E3 Ligases and Directed Degradation Chimeras (PROTACs)
26. Pathology III: Sarcopenia and Muscle Atrophy
27. Pathology IV: Systemic Amyloidosis and Infections
28. · Pathophysiology of Systemic Amyloidosis
29. · Subversion of the UPS by Viral Pathogens
30. Diagnosis and Research Methods in Proteolysis
31. Protein Degradation Systems