Clinical Biochemistry: Insulin Resistance Indices — Scientific Reference Guide

Biochemistry · Basic Sciences

How it begins

Análisis exhaustivo y de nivel de experto sobre los fundamentos bioquímicos, formulación matemática, estandarización analítica y relevancia clínica de los métodos diagnósticos de resistencia a la insulina, desde los estándares de referencia clásicos hasta los biomarcadores lipoproteicos de última generación.

What it covers

1. Molecular Signaling of the Insulin Receptor
2. Molecular Mechanisms of Interference in Signaling
3. Mitochondrial Dysfunction and Oxidative Stress
4. Low Grade Chronic Inflammation and Adipokines
5. Hyperinsulinemic-Euglycemic Clamp
6. Frequently Sampling Intravenous Glucose Tolerance Test (FSIGT) and Minimal Model
7. Dynamic Indices Derived from the Oral Glucose Tolerance Test
8. · Matsuda Insulin Sensitivity Index (Composite Index)
9. HOMA-IR and the Evolution of the HOMA2 Computational Model
10. · The transition to the HOMA2 computational model
11. QUICKI (Quantitative Insulin Sensitivity Check Index)
12. Fasting Insulin/Glucose Ratio
13. The TyG Index (Triglycerides and Glucose)
14. Anthropometric Variants of the TyG Index
15. Triglycerides/HDL Cholesterol Ratio (TG/HDL-C)
16. METS-IR (Metabolic Score for Insulin Resistance)
17. Leptin/Adiponectin and Adipokine Relationship
18. NMR Lipoprotein Profile (LP-IR Index)
19. Free Fatty Acids and Proinsulin/Insulin Ratio
20. · Kinetics of Free Fatty Acids (FFA / FFA)
21. · The Proinsulin/Intact Insulin Ratio as a biomarker of cellular dysfunction
22. Emerging Biomarkers: FGF21, RBP4, Fetuin-A and Adipsin
23. Heterogeneity and Challenges of Insulin Immunoassays
24. Mass Spectrometry as an Analytical Reference Method
25. Type 2 Diabetes Mellitus and Beta Cell Failure
26. Polycystic Ovary Syndrome (PCOS)
27. MASLD / MASH (Metabolic Fatty Liver Disease)
28. Metabolic Syndrome and Cardiovascular Risk