Clinical Biochemistry · Pathophysiology and Bone Metabolism

Biochemistry · Basic Sciences

How it begins

Fisiopatología, biología molecular y diagnóstico bioquímico de los trastornos del tejido esquelético. Esta obra describe de manera sistemática los mecanismos intracelulares , las interacciones endocrinas de los minerales y los biomarcadores séricos que guían la toma de decisiones clínicas.

What it covers

1. Molecular biology of bone and matrix synthesis
2. · The bone matrix: organic and inorganic ultrastructure
3. · Physiology of bone cell lineages
4. Calcium dynamics: absorption, transport and renal management
5. · Serum calcium fractions and their dependence on pH
6. · Intestinal absorption of Calcium
7. · Renal Calcium Management
8. Phosphate and Magnesium Metabolism: molecular interactions
9. · Phosphate Regulation: intestinal absorption and Sodium-Phosphate cotransporters
10. · Renal Phosphate Physiology: proximal reabsorption and phosphatenins
11. · Magnesium pathophysiology: renal absorption and management
12. The PTH - Vitamin D - FGF23 Axis: the homeostatic triad
13. · Parathyroid hormone (PTH): synthesis, secretion and signal transduction
14. · Vitamin D: biosynthesis and hydroxylation pathways
15. · Fibroblast Growth Factor 23 (FGF23)
16. Bone Remodeling Markers (BRO) and their analytical interpretation
17. · Classification of Bone Remodeling Markers
18. Osteoporosis and Endocrinopathies with skeletal impact
19. · Immunopathogenic Postmenopausal Osteoporosis (Type I)
20. · Senile Osteoporosis (Type II): mitochondrial and cellular decline
21. · Endocrinopathies and their destructive impact on bone
22. Pathophysiology of Rickets and Osteomalacia
23. · Molecular mechanisms of the mineralization defect
24. Paget's Bone Disease Pathophysiology
25. · Genetic and molecular bases of osteoclastic hyperactivity
26. · Phases of the disease and their biochemical correlation
27. Hyperparathyroidism and the Pathophysiology of FHH
28. · Mechanisms of Pathophysiology of Hyperparathyroidism
29. · Familial Hypocalciuric Hypercalcemia (FHH): a CaSR calibration error
30. Renal Osteodystrophy and the CKD-MBD Complex
31. · The pathophysiological cascade of CKD-MBD
32. Hypercalcemia of Malignancy and Bone Metastases
33. · Physiopathological mechanisms of oncological hypercalcemia
34. Molecular Biology of Osteogenesis Imperfecta and Osteopetrosis
35. · Osteogenesis Imperfecta: the fragility of the collagen matrix
36. · Osteopetrosis: failure of resorption and the "marble bone"
37. Algorithms for Differential Diagnosis of Calcium and Phosphate disorders
38. · Algorithm 1: Diagnostic Approach to Hypercalcemia
39. · Algorithm 2: Diagnostic Approach to Hypocalcemia
40. Bone Metabolism Therapy and its Biochemical Monitoring
41. · Antiresorptive Pharmacology: inhibition of the osteoclast pathway
42. · Anabolic or Osteoforming Pharmacology: osteoblast stimulation
43. · Biochemical Treatment Monitoring Protocol