Clinical Biochemistry — Iron Metabolism

Biochemistry · Basic Sciences

How it begins

Un análisis molecular exhaustivo del balance del hierro. Desde la coordinación química de los orbitales d de los iones ferrosos y férricos, pasando por los mecanismos de absorción enterocitaria, el complejo de transporte plasmático mediado por transferrina, hasta la exquisita regulación hormonal sistémica ejercida por la hepcidina y la retroalimentación intracelular controlada por el sistema IRE/IRP.

What it covers

1. Physicochemistry of Iron and Cellular Toxicity
2. · The Haber-Weiss and Fenton Reactions
3. · Body Iron Distribution
4. Iron Absorption and Enterocyte Physiology
5. · The Absorption Process of Non-Heme Iron
6. Plasma Transport and Cellular Uptake
7. · The Transferrin Coordinated Union
8. · The Transferrin Receptor 1 (TfR1) Endocytosis Cycle
9. Cellular Iron Storage: Ferritin and Hemosiderin
10. · Quaternary Structure and Subunits of Ferritin
11. · Hemosiderin: Insoluble Deposit
12. · Iron Release: The Mechanism of Ferritinophagy mediated by NCOA4
13. The Role of Macrophages and Iron Recycling
14. · The Physiological Mechanism of Erythrophagocytosis
15. Systemic Regulation by Hepcidin and the Inflammatory Axis
16. · The Mechanism of Cellular Action of Hepcidin
17. · Hepcidin Transcriptional Signaling Pathways (HAMP)
18. · Suppression of Hepcidin due to Erythroid Demand: Erythroferrone (ERFE)
19. Intracellular Regulation: The IRE/IRP System
20. · Iron Response Elements (IRE)
21. · The Behavior of IRP1 and IRP2 according to the Iron Status
22. Biochemistry of the Hemo Group and its Coordination
23. · The Metabolic Route of Heme Synthesis
24. Laboratory Methods and Advanced Clinical Diagnosis
25. · Iron Profile Parameters and Biochemical Interpretation
26. · Quantification of Iron Overload by Liver MRI (T2*)
27. Clinical Correlation: Iron Deficiency Anemia
28. · Pathophysiological Evolution of Iron Deficiency
29. Clinical Correlation: Anemia of Chronic Disorders
30. · Physiopathological Mechanism of Molecular Iron Sequestration
31. · Differential Diagnostic Algorithm: Pure iron deficiency vs. Anemia of Chronic Disorders
32. Clinical Correlation: Hereditary Hemochromatosis
33. · Genetic Classification of Hereditary Hemochromatosis
34. · The Classical Clinical Pentad of Organ Damage
35. Secondary Iron Overload and Marrow Insufficiency
36. · The Pathophysiology of Transfusional Iron Load
37. · Mechanism of Action of Iron Chelating Drugs
38. Ferroptosis: Iron-Dependent Regulated Cell Death
39. · Biochemical Mechanisms of Ferroptosis Induction
40. · Clinical Correlations and Pathological Implication of Ferroptosis