Clinical Biochemistry — Free Radicals, Oxidants and Antioxidants

Biochemistry · Basic Sciences

How it begins

Análisis termodinámico, fisiopatológico y molecular de los sistemas redox celulares, su regulación genética, implicaciones patológicas de alta frecuencia y técnicas analíticas avanzadas de diagnóstico clínico

What it covers

1. Thermodynamics and Redox Electronic Morphology
2. Physiology and Cellular Sources of Oxidants
3. · 1.1 Electron Leakage in the Mitochondrial Electron Transport Chain
4. · 1.2 The NADPH Oxidase Enzyme Complex (NOX)
5. · 1.3 Transition from Xanthine Dehydrogenase to Xanthine Oxidase
6. · 1.4 Uncoupling of Nitric Oxide Synthases (NOS)
7. Molecular Pathophysiology and Macromolecular Damage
8. · 2.1 Lipid Peroxidation of Cell Membranes
9. · 2.2 Protein Oxidation and Carbonylation
10. · 2.3 Oxidative Damage to DNA: Genotoxicity and Mutagenesis
11. The Endogenous Antioxidant Arsenal
12. · 3.1 Superoxide Dismutases (SOD)
13. · 3.2 Catalase (CAT)
14. · 3.3 The Glutathione Peroxidase and Glutathione Reductase Cycle
15. · 3.4 The Thioredoxin and Peroxiredoxin System
16. · 3.5 Non-enzymatic and Low Molecular Weight Antioxidants
17. Cell Signaling and Genomic Redox Regulation
18. · 4.1 The Keap1-Nrf2-ARE Electrophilic and Antioxidant Response Pathway
19. · 4.2 Redox Activation of the NF-B Proinflammatory Pathway
20. · 4.3 Second Molecular Messengers: Hydrogen Peroxide and the Regulation of Phosphatases
21. Pathophysiology of Common Clinical Diseases
22. · 5.1 Atherogenesis and Oxidation of Low Density Lipoproteins (LDL)
23. · 5.2 Redox Pathophysiology in Type 2 Diabetes Mellitus (T2DM)
24. · 5.3 Neurodegenerative Diseases: Brain and Iron
25. · 5.4 Carcinogenesis and the Dual Role of ROS in Oncology
26. Laboratory Diagnosis and Redox Biomarkers
27. · 6.1 Direct Detection: Electronic Paramagnetic Resonance (EPR)
28. · 6.2 Indirect Detection: Panel of Clinical Oxidation Biomarkers
29. · 6.3 Global Antioxidant Capacity Tests
30. Pharmacology, Nutraceuticals and the Antioxidant Paradox
31. · 7.1 The Antioxidant Paradox in Evidence-Based Medicine
32. · 7.2 Endogenous Pharmacological Activation of Nrf2
33. · 7.3 Molecular Mimics of Redox Enzymes
34. · 7.4 Pharmacology Targeted at the Mitochondria: MitoQ and SS Peptides
35. · Redox Balance as a Pillar of Human Life