Neuromuscular Diseases — Treatise on Internal Medicine

Neurosciences · Basic Sciences

How it begins

Del asta anterior al sarcómero: fisiopatología, semiología, electrodiagnóstico y abordaje clínico integral de los trastornos de la unidad motora.

What it covers

1. Tabula Materiae
2. The motor unit: architecture and physiology
3. · The four anatomical links
4. · The lower motor neuron and the recruitment principle
5. · The neuromuscular junction: a synapse with a safety margin
6. · The muscle fiber: from potential to sarcomere
7. Topographic classification and differential semiology
8. · The pattern of weakness as a compass
9. · Neurogenic versus myopathic: the cardinal distinction
10. · Positive symptoms: the vocabulary of the neuromuscular patient
11. · The directed physical examination
12. Electrodiagnosis and complementary tools
13. · Nerve conduction studies (neurography)
14. · Needle electromyography (EMG)
15. · Repetitive nerve stimulation and single fiber
16. · Serum markers
17. · Muscle and nerve biopsy
18. · Image and genetics
19. Motor neuron diseases
20. · Amyotrophic lateral sclerosis (ALS)
21. · Variants of the motor neuron spectrum
22. · Spinal muscular atrophy (SMA)
23. · Bulbospinal muscular atrophy (Kennedy's disease)
24. Peripheral neuropathies
25. · An operational taxonomy
26. · Guillain-Barré syndrome (GBS)
27. · Chronic inflammatory demyelinating polyneuropathy (CIDP)
28. · Diabetic neuropathy
29. · Hereditary neuropathies: Charcot-Marie-Tooth
30. · Neuropathies due to specific mechanisms
31. Neuromuscular junction disorders
32. · Myasthenia gravis
33. · Lambert-Eaton myasthenic syndrome (LEMS)
34. · Botulism
35. · Congenital myasthenic syndromes
36. Inflammatory and autoimmune myopathies
37. · Dermatomyositis (DM)
38. · Polymyositis (PM)
39. · Immune-mediated necrotizing myopathy (IMNM)
40. · Inclusion body myositis (IBM)
41. · Anti-synthetase syndrome
42. · Treatment principles
43. Muscular dystrophies and myotonias
44. · Dystrophinopathies: Duchenne and Becker
45. · Limb-girdle dystrophies (LGMD)
46. · Facioscapulohumeral dystrophy (FSHD)
47. · Emery-Dreifuss dystrophy
48. · Oculopharyngeal dystrophy
49. · Myotonic dystrophies: multisystem disease
50. Metabolic, endocrine and toxic channelopathies and myopathies
51. · Muscular channelopathies
52. · Metabolic myopathies
53. · Endocrine myopathies
54. · Toxic myopathies and critical patients
55. · Rhabdomyolysis
56. Neuromuscular emergencies
57. · Neuromuscular respiratory failure
58. · Myasthenic crisis
59. · Guillain-Barré Dysautonomia
60. · Related hyperthermic syndromes
61. · Hyperkalemia and severe rhabdomyolysis
62. Synthesis: integrated reasoning
63. · The algorithm for the patient with weakness
64. · Location master chart
65. · Diagnostic errors that change lives