Pharmacology: Respiratory System

Pharmacology: Respiratory System — Expert Reference

How it begins

Revisión exhaustiva de los grupos farmacológicos activos sobre el sistema respiratorio: broncodilatadores, antiinflamatorios, biológicos, mucolíticos, moduladores de la vasculatura pulmonar y terapias génico-farmacológicas emergentes, con énfasis en mecanismo de acción molecular, farmacocinética y correlación clínica.

What it covers

1. Pharmacological Bases of the Respiratory System
2. · Autonomic Physiology of the Airway: The Substrate of Pharmacology
3. Inhalation and Pulmonary Depot Devices
4. · Particle Size and Deposit
5. Pharmacokinetics of Inhaled Drugs
6. β₂-Adrenergic agonists
7. · 4.1 Short-Acting β₂ Agonists (SABA)
8. · 4.2 Long-Acting β₂ Agonists (LABA)
9. · 4.3 Ultra-LABAs (24h LABA) — For COPD
10. Anticholinergic (Antimuscarinic) Drugs
11. · 5.1 SAMA — Ipratropium Bromide
12. · 5.2 LAMA — Long-Acting Anticholinergics (24h)
13. Methylxanthines: Theophylline and Aminophylline
14. · Theophylline — The Multipurpose Bronchodilator
15. Inhaled Corticosteroids (ICS)
16. · 7.1 Molecular Mechanism of Glucocorticoids
17. · 7.2 Available ICS: Pharmacological Comparison
18. Systemic Corticosteroids in Respiratory Pathology
19. · Use in Severe Acute Asthmatic Crisis
20. · Use in Acute COPD
21. Leukotriene Modifiers
22. · CysLT₁ Receptor Antagonists (CysLTRA)
23. · 5-LOX inhibitors: Zileuton
24. Sodium Cromoglycate and Nedocromil
25. Biological Therapy in Severe Asthma
26. · 11.1 Anti-IgE: Omalizumab
27. · 11.2 Anti-IL-5 / Anti-IL-5Rα: The Antieosinophilic Arsenal
28. · 11.3 Anti-IL-4Rα: Dupilumab
29. · 11.4 Anti-TSLP: Tezepelumab (Tezspire®)
30. Mucolytics, Mucokinetics and Expectorants
31. Antitusivos
32. Exogenous Surfactant
33. Pharmacology of Pulmonary Arterial Hypertension (PAH)
34. · 15.1 Prostacyclin Analogues
35. · 15.2 Endothelin Receptor Antagonists (ERA)
36. · 15.3 PDE5 inhibitors
37. · 15.4 Soluble Guanylate Cyclase (sGC) Stimulators
38. CFTR Modulators for Cystic Fibrosis
39. Oxygen therapy, Respiratory Stimulants and Ventilation
40. · Chronic Home Oxygen Therapy (OCD)
41. · High Flow Nasal Cannula (HFNC)
42. · Respiratory Stimulants
43. Stepped Treatment of Asthma (GINA 2024)
44. Pharmacotherapy of COPD (GOLD 2024)
45. · Use of ICS in COPD: The Eosinophil Guide
46. · Prophylactic Azithromycin in COPD: The Antibiotic as Anti-inflammatory
47. Relevant Drug Interactions
48. Pharmacological Glossary
49. Bibliography and Clinical Reference Guides
50. · Fundamental Texts
51. · Clinical Guidelines
52. · Seminal Articles