Immunology: Innate Immunity

Immunology: Innate Immunity — Expert Reference

How it begins

La primera línea de defensa del organismo: mecanismos celulares y moleculares de reconocimiento inmediato del peligro, respuesta inflamatoria y control del daño tisular. Una revisión exhaustiva de nivel experto.

What it covers

1. Overview of the Immune System
2. Fundamental Characteristics
3. · 2.1 Pattern Specificity vs. Clonal Specificity
4. · 2.2 Defining Properties
5. · 2.3 Trained Immunity (Innate Memory)
6. Physical-Chemical and Biological Barriers
7. · 3.1 The Epithelial Barrier
8. · 3.2 The Mucous Barrier
9. · 3.3 The Microbiota as a Biological Barrier
10. Pattern Recognition Receivers (PRRs)
11. · 4.1 Toll-like receptors (TLRs)
12. · 4.2 NOD-like Receptors (NLRs)
13. · 4.3 RIG-I-like Receivers (RLRs)
14. · 4.4 C-type Lectin Receptors (CLRs)
15. · 4.5 The cGAS-STING Route
16. PAMPs, DAMPs and Danger Theory
17. · 5.1 PAMPs
18. · 5.2 DAMPs and Danger Theory
19. Innate Immunity Cells
20. · 6.1 Neutrophils (PMN)
21. · 6.2 Macrophages
22. · 6.3 Dendritic Cells (DCs)
23. · 6.4 Natural Killer (NK) Cells
24. · 6.5 Mast Cells and Basophils
25. · 6.6 Eosinophils
26. · 6.7 Innate Lymphoid Cells (ILCs)
27. Complement System
28. · 7.1 Three Ways of Activation
29. · 7.2 Effector Functions of the Complement
30. Phagocytosis and Microbial Destruction Mechanisms
31. · 8.1 Phagocytosis: A Multistep Process
32. NETosis: Neutrophil Extracellular Traps
33. · 9.1 NETosis Mechanisms
34. · 9.2 Antimicrobial Function and Pathology
35. The Inflammasome and Pyroptosis
36. · 10.1 The NLRP3 Inflammasome: Architecture and Two-Step Signal
37. · 10.2 Inflammasome Structure and Signaling
38. · 10.3 Pyroptosis
39. · 10.4 Other Relevant Inflammasomes
40. Interferons: The Innate Antiviral Response
41. · 11.1 JAK-STAT Pathway: Type I IFN Signaling
42. Cytokines and Lipid Mediators of Innate Inflammation
43. · 12.1 Main Pro-inflammatory Cytokines
44. · 12.2 Lipid Mediators
45. The Acute Phase Response (APR)
46. · 13.1 Acute Phase Proteins
47. · 13.2 Systemic Manifestations of the Inflammatory Response
48. Sepsis: The Innate Dysregulated
49. · 14.1 Pathophysiology: From Infection to Organic Dysfunction
50. · 14.2 The Immunosuppressive Paradox
51. · 14.3 Biomarkers and Precision Medicine in Sepsis
52. Monogenic Autoinflammatory Diseases
53. Primary Immunodeficiencies of Innate Immunity
54. SARS-CoV-2: Innate Immunity in the Pandemic
55. · 17.1 Evasion of the Innate Response by SARS-CoV-2
56. · 17.2 The Cytokine Storm and ARDS
57. · 17.3 Genetic Innate Immunodeficiency and Severe COVID-19
58. Innate Immunity and Cancer
59. · 18.1 Innate Immune Surveillance
60. · 18.2 The Tumor Microenvironment: Subversion of the Innate
61. · 18.3 Therapies Directed at Innate in Oncology
62. The Innate-Adaptive Nexus: Specific Response Instruction
63. · 19.1 Principles of Innate Control over Adaptive Control
64. · 19.2 The Dendritic Cell as Orchestra Conductor
65. · 19.3 Memory: Beyond the Adaptive
66. · 19.4 Summary of Clinical Correlations by Mechanism
67. Resolution of Inflammation: An Active and Programmed Process
68. · 20.1 The Temporal Curve of Inflammation and Resolution
69. · 20.2 Specialized Resolution Mediators (SPMs)
70. · 20.3 Cellular Resolution Mechanisms
71. · 20.4 Chronic Inflammation: The Failure of Resolution
72. Innate Immunity in Specific Tissues
73. · 21.1 The Central Nervous System: The Microglia
74. · 21.2 The Liver: Kupffer Cells and Hepatic Immune Tolerance
75. · 21.3 The Lung: Alveolar Macrophages and the Air-Blood Interface
76. · 21.4 The Skin: Langerhans Cells and Dermal Macrophages
77. · 21.5 The Intestine: The GALT and the Innate Mucosal Cells
78. Therapeutic Perspectives: Modulating Innate Immunity
79. · 22.1 Cytokine Inhibitors and Their Receptors
80. · 22.2 Inhibitors of Intracellular Signaling Pathways
81. · 22.3 Complement Modulation
82. · 22.4 PRR Agonists: Activate Innate for Benefit
83. Glossary of Key Terms
84. Select Reference Bibliography
85. · Fundamental Reference Texts
86. · Seminal Articles — Innate
87. · Clinical and Therapeutic Correlations