Pain Medicine — Anatomy, Physiology and Pathophysiology

Pain Medicine · Clinical Specialties

How it begins

Estudio minucioso de los mecanismos de transducción, transmisión sináptica en el asta dorsal, vías ascendentes, procesamiento cortical, modulación descendente y la neurobiología celular de la sensibilización periférica y central.

What it covers

1. Introduction and Taxonomy of Pain (IASP)
2. · Critical Differences: Acute Pain vs. Chronic Pain
3. · Clinical Glossary of Sensory Terminology
4. Anatomy of the Peripheral Nociceptive System
5. · Primary Afferent Fibers
6. · Ion Channels and Membrane Receptors in Transduction
7. · Voltage Dependent Sodium Channels (NaV)
8. · The Tissue Inflammatory Soup
9. Transmission and Synapses in the Dorsal Horn
10. · Cytoarchitecture of the Dorsal Horn (Rexed Sheets)
11. · Neurotransmitters and Interneurons in the Spinal Microcircuit
12. · Gate Control Theory
13. Ascending Pathways of Pain: Supraspinal Projection
14. · The Main Projection Tracts
15. Supraspinal Processing and the "Pain Matrix"
16. Downward Modulation of Pain: Endogenous System
17. · The Periaqueductal-Bulborreticular Pathway
18. · ON and OFF cells of the Rostral Ventromedial Medulla
19. · Neurochemistry of Endogenous Opioids
20. · Diffuse Inhibitory Modulation Induced by Noxious Stimuli (DNIC / CPM)
21. Pathophysiology of Peripheral Sensitization
22. · The Intracellular Cascade of Sensitization
23. · Neurogenic Inflammation
24. Pathophysiology of Central Sensitization
25. · The Temporal Summation Phenomenon ("Wind-up")
26. · The NMDA Receptor Cascade and Long-Term Potentiation (LTP)
27. · Glial Activation and Spinal Neuroinflammation
28. · Aberrant Structural Reorganization (Aβ Fiber Sprouting)
29. Pathophysiology of Neuropathic Pain
30. · Cellular Mechanisms of Neuropathic Pain
31. · Key Clinical Neuropathic Syndromes
32. Nociplastic Pain and Central Sensitization
33. · Molecular Pathophysiology of Fibromyalgia
34. · Complex Regional Pain Syndrome (CRPS Type I and II)
35. Clinical Pharmacology Applied to Pain
36. · Cellular Action Mechanisms by Pharmacological Group
37. · Opioid-Induced Hyperalgesia (OIH)
38. Physiology of Visceral Pain
39. · Physiological Differences of Visceral Pain vs. Somatic
40. · The Pathophysiology of Referred Pain (Convergence-Projection Theory)
41. Pain in Special Populations
42. · Particularities of Pediatric and Neonatal Nociception
43. · Geriatric Pain and Senile Processing Modifications
44. Clinical Approach and Interventional Pain
45. · Interventional Techniques in Refractory Pain