Pain Medicine — Fundamentals, Pathophysiology and Clinical Evaluation

Pain Medicine · Clinical Specialties

How it begins

Un tratado exhaustivo y sistemático sobre los mecanismos moleculares de la nocicepción, la modulación segmentaria y supraespinal, los síndromes de sensibilización periférica y central, la epidemiología contemporánea y las bases metodológicas para la evaluación diagnóstica multidimensional del paciente algológico.

What it covers

1. Historical and Conceptual Introduction
2. · The IASP Definition: Exegetical Analysis (1979 vs. 2020)
3. · Pain as "Fifth Vital Sign": Rise, Fall and New Paradigm
4. Global Epidemiology and Burden of Disease
5. · Prevalence of Major Chronic Painful Pathologies
6. · Sexual Dimorphism and Gender Differences in Algos
7. · The Socioeconomic Cost of Pain
8. Taxonomic Classification of Pain
9. · Classification of Chronic Pain according to the ICD-11
10. Neuroanatomy of Nociception: Receptors and Afferent Pathways
11. · Molecular Biology of Nociceptive Transduction
12. · Biophysics of Action Potential Generation: Sodium Channels
13. · Primary Afferent Fibers: Biophysical and Histological Characteristics
14. Spinal Transmission and Modulation
15. · Rexed Cytoarchitecture in Nociceptive Processing
16. · The Central Nociceptive Synapse: Neurotransmitters and Receptors
17. · The Referred Pain Phenomenon: Viscerosomatic Convergence
18. Ascending Pathways and Supraspinal Centers
19. · The Great Ascending Highways of Pain
20. · The "Pain Matrix" and Cortical Integration
21. Downward Pain Modulation
22. · The Periaqueductal Gray Matter Axis - Ventromedial Rostral Medulla
23. · Neurochemistry of Descending Inhibition
24. · Conditioned Pain Modulation (Pain Inhibits Pain / DNIC)
25. Physiology of Peripheral Sensitization
26. · The "Inflammatory Soup" and its Intracellular Cascades
27. · Neurogenic Inflammation: Antidromic Axonal Reflex
28. Physiology of Central Sensitization
29. · The Synaptic Cascade of NMDA Receptor Unlocking
30. · Glial Activation and Spinal Neuroinflammation
31. · The Phenotype Change of Aβ Fibers (A-beta Phenotypic Switch)
32. Neuropathic Pain: Advanced Pathophysiology
33. · Ectopic Pacemaker Generation Mechanisms
34. · Sympathetic-Sensory Coupling
35. · Death from Excitotoxicity and Loss of Segmental Braking
36. Nociplastic and Central Sensitization Pain
37. · Comparative Pathophysiology of Major Nociplastic Disorders
38. · The Default Mode Network (DMN) and Chronification of Pain
39. Multidimensional Clinical Assessment of Pain
40. · Systematic Semiology of Pain: Mnemonics ALICIA
41. · Unidimensional and Multidimensional Measurement Scales
42. · Directed Sensory Physical Examination: Key Terminology
43. Clinical Variants and Special Populations
44. · Evaluation of Pain in Critical Care (ICU)
45. Basic Clinical-Pharmacological Correlations
46. · Physiopathological Target of the Main Analgesic Families