Neurooncology and Systemic Disorders

Neuro-oncology and Systemic Disorders — Internal Medicine

How it begins

Un compendio exhaustivo y riguroso de la afección del sistema nervioso central y periférico en el paciente oncológico: biología de los tumores primarios y metastásicos, síndromes inmunomediados paraneoplásicos, neurotoxicidad terapéutica y manifestaciones neurológicas secundarias de las discrasias hematológicas y metabólicas sistémicas.

What it covers

1. Neurooncology and Systemic Disorders
2. Classification and Epidemiology of CNS Neoplasms
3. · Epidemiology and Clinical Relevance
4. · Molecular Architecture of Adult Gliomas
5. Pathophysiology of the Brain Tumor Microenvironment
6. · The Neurovascular Unit (VNU) and the Blood-Brain Barrier (BBB)
7. · Pathophysiology of Vasogenic Edema
8. · Immunoprivilege and Immune Escape
9. Brain Metastases from Solid Tumors
10. · Hematogenous Dissemination Cascade and "Homing"
11. · Distribution and Frequency by Primary Origin
12. Leptomeningeal and Epidural Commitment
13. · Leptomeningeal Metastases (Meningeal Carcinomatosis)
14. · Spinal Cord Epidural Compression (CEME)
15. Paraneoplastic Syndromes: Antibodies Against Intracellular Antigens
16. · Pathophysiology of Antibodies against Intracellular Antigens
17. · Classic Onconeuronal Antibody Spectrum
18. Paraneoplastic Syndromes: Cell Surface and Synaptic Antibodies
19. · Pathophysiology of the Antigen-Antibody Interaction on the Surface
20. · Main Surface Autoimmune Encephalitis with Oncological Association
21. · General Treatment of Paraneoplastic Autoimmune Encephalitis
22. Direct Neurological Complications of Cancer and Opportunistic Infections
23. · Cerebrovascular Complications of Cancer
24. · Opportunistic CNS Infections
25. Neurotoxicity due to Conventional Chemotherapy
26. · Chemotherapy-Induced Peripheral Neuropathy (CIPN)
27. · Methotrexate (MTX)-Induced Leukoencephalopathy
28. Neurotoxicity from Targeted Therapies and Immunotherapy
29. · Immune-Mediated Neurological Adverse Events (irAEs) due to ICIs
30. · Immune Effector Cell Neurotoxicity Syndrome (ICANS) due to CAR-T
31. Neurological Complications from Radiotherapy
32. · Temporal Classification of Radiotoxicity
33. · Late-delayed Cerebral Radionecrosis
34. Symptomatic and Supportive Management in Neuro-oncology
35. · Rational Use of Corticosteroids
36. · Epileptic Seizure Control
37. · Venous Thromboembolism (VTE) and Anticoagulation
38. Systemic Disorders (I): Endocrinopathies and Oncological Metabolopathies
39. · Syndrome of Inappropriate ADH Secretion (SIADH) and Hyponatremia
40. · Humoral Hypercalcemia of Malignancy (HHM)
41. Systemic Disorders (II): Hematological Dyscrasias and Hyperviscosity Syndromes
42. · Rheological Pathophysiology of Hyperviscosity Syndrome (HVS)
43. · Leukostasis in Acute Leukemias
44. Multimodal Diagnostic Approach in Neuro-oncology
45. · Advanced Neuroimaging Techniques by MRI
46. · Positron Emission Tomography (PET) with Amino Acids
47. · The Revolution of Liquid Biopsy in CSF
48. Clinical Algorithms and Multidisciplinary Approach
49. · Management Algorithm for the Appearance of Neurological Focality or De Novo Headache
50. · Approach Algorithm for Suspected Paraneoplastic Syndrome