Tissue Repair — General Pathology

General Pathology · Basic Sciences

How it begins

La reparación tisular es el proceso mediante el cual el organismo reemplaza o restituye los tejidos dañados por lesión o muerte celular. Es la respuesta natural que sigue a toda lesión tisular y que se inicia de forma solapada con la fase de inflamación, constituyendo junto a ella un proceso integrado de respuesta al daño.

What it covers

1. Tissue Repair
2. Concept and Overview
3. · Determinants of the Repair Result
4. · The Regeneration Continuum — Fibrosis
5. Regeneration vs Healing
6. · When does it regenerate and when does it heal?
7. Cellular Proliferative Capacity
8. · The Cellular Cycle in Repair
9. · Tissue Stem Cell Niches
10. Repair Phases — Wound Healing
11. · Phase 1 — Hemostasis and Inflammation (0 h – 5 days)
12. · Phase 2 — Proliferation: Granulation Tissue (Days 3 – 14)
13. · Phase 3 — Wound Contraction and Remodeling (Days 7 – Years)
14. Healing by First Intention
15. Healing by Second Intention
16. · Key Histological Differences
17. Repair Cells
18. · Fibroblast and Myofibroblast
19. · The Repair Macrophage — M2
20. · Tissue Stem Cells in Repair
21. Growth Factors in Repair
22. Extracellular Matrix in Repair
23. · Composition of the MEC in Each Phase
24. · Collagen — The Main Structural Component
25. · Proteoglycans and Glycoproteins — Regulatory Components
26. Angiogenesis in Repair
27. · Mechanism of Sprouting Angiogenesis
28. · Vasculogenesis vs Angiogenesis
29. Fibrosis — Excessive and Pathological Repair
30. · Pathogenesis of Fibrosis — The Positive Feedback Loop
31. · Fibrosis in Specific Organs — Key Cells
32. Factors that Modify the Repair
33. · Systemic Factors
34. · Local Factors
35. Pathological Scars
36. Liver Repair
37. · Acute Liver Regeneration — The Partial Hepatectomy Model
38. · Liver Fibrosis → Cirrhosis — The Stellate Cell of Ito
39. · Liver Fibrosis Staging — METAVIR System
40. Lung Repair
41. · Diffuse Alveolar Damage (DAD) — The Response to Acute Lung Injury
42. · Idiopathic Pulmonary Fibrosis (IPF) — The Progressive Fibrosis Prototype
43. Kidney Repair
44. · Repair in Acute Tubular Necrosis (ATN)
45. · Tubulointerstitial Fibrosis — The Final Common Pathway of CKD
46. Cardiac Repair
47. · Post-Myocardial Infarction Repair
48. · Can the Heart Regenerate?
49. Repair in the CNS
50. · Reactive Gliosis — The "Scar" of the CNS
51. · Strategies to Promote CNS Regeneration
52. Pro-reconstructive and Antifibrotic Therapies
53. · Wound Treatment — Pathogenic Basis
54. · Antifibrotic Treatments
55. Integration and Final Perspective
56. · Synthesis: Regeneration vs Healing in the Main Organs
57. · Therapeutic Targets of the Future
58. · Summary of Key Concepts
59. · Bibliographical References