General Pathology: Inflammation

General Pathology: Inflammation — Expert Reference

How it begins

Respuesta vascular, celular y molecular al daño tisular: mecanismos moleculares, mediadores, morfología, resolución y reparación. Patología general con correlaciones clínicas exhaustivas.

What it covers

1. Concept, History and Conceptual Framework
2. · 1.1 The Five Cardinal Signs of Celsus and Virchow
3. · 1.2 Acute Inflammation vs. Chronicle: Essential Differences
4. · 1.3 Causes of Inflammation
5. Components of the Inflammatory Response
6. · 2.1 The Central Role of Hazard Recognition
7. Vascular Changes in Acute Inflammation
8. · 3.1 Vasodilatation: Molecular Mechanisms
9. · 3.2 Increase in Vascular Permeability: Mechanisms
10. · 3.3 The Inflammatory Exudate: Composition and Function
11. · 3.4 Changes in Blood Flow: From Flushing to Stasis
12. Leukocyte Recruitment: The Adhesion Cascade
13. · 4.1 The Adhesion Cascade: Phases and Molecules
14. · 4.2 Chemotaxis and Neutrophil Activation
15. · 4.3 Cellular Recruitment Sequence
16. Chemical Mediators of Inflammation
17. · 5.1 Vasoactive Amines
18. · 5.2 Eicosanoids: The Arachidonic System
19. · 5.3 Kinin System
20. · 5.4 The Complement System
21. · 5.5 Proinflammatory Cytokines
22. · 5.6 Platelet Activating Factor (PAF)
23. · 5.7 Coagulation System as an Inflammatory Mediator
24. Results and Morphology of Acute Inflammation
25. · 6.1 Results of Acute Inflammation
26. · 6.2 Morphological Patterns of Acute Inflammation
27. Chronic Inflammation: Cells and Mechanisms
28. · 7.1 Causes of Chronic Inflammation
29. · 7.2 The Macrophage: Central Protagonist
30. · 7.3 Lymphocytes in Chronic Inflammation
31. Granulomatous Inflammation
32. · 8.1 Composition of the Granuloma
33. · 8.2 Granuloma Formation: Molecular Signaling
34. · 8.3 Etiological Classification of Granulomas
35. The Systemic Response to Inflammation
36. · 9.1 The Acute Phase Response
37. · 9.2 SIRS, Sepsis and Septic Shock: The Inflammatory Continuum
38. Resolution of Inflammation: An Active Process
39. · 10.1 Pro-Resolution Signals
40. · 10.2 Epherocytosis: Key to the Resolution
41. Principles of Tissue Repair
42. · 11.1 Regenerative Capacity: Cell Classification
43. · 11.2 Growth Factors in Repair
44. Wound Healing: Phases and Biology
45. · 12.1 Phase I: Hemostasis (0–Hours)
46. · 12.2 Phase II: Inflammation (Hours–Days 1–5)
47. · 12.3 Phase III: Proliferation (Days 2–21)
48. · 12.4 Phase IV: Remodeling (Weeks–Years)
49. Fibrosis: Excessive and Pathological Repair
50. · 13.1 The Myofibroblast: Central Cell of Fibrosis
51. · 13.2 TGF-β: The Master of Fibrosis
52. · 13.3 Organic Fibrosis: Pathology and Correlations
53. Morphological Patterns of Cellular and Tissue Injury
54. · 14.1 Necrosis: Types and Morphology
55. · 14.2 Cell Death: Apoptosis vs. Necrosis vs. Pyroptosis vs. Necroptosis
56. Relevant Chronic Inflammatory Diseases
57. Sterile Inflammation and Autoinflammatory Diseases
58. · 16.1 Gout and Gouty Arthritis: The Prototype of Crystal Inflammation
59. · 16.2 Atherosclerosis: Chronic Sterile Inflammation of the Arterial Wall
60. Chronic Inflammation and Carcinogenesis
61. · 17.1 Mechanisms by which Inflammation Promotes Cancer
62. · 17.2 Examples of Inflammatory Carcinogenesis
63. Inflammatory Biomarkers in the Clinic
64. Anti-inflammatory Pharmacology: Mechanisms and Applications
65. Glossary of Key Terms
66. Select Reference Bibliography
67. · Fundamental Texts of Pathology
68. · Mediators and Biology of Inflammation
69. · Tissue Repair and Fibrosis
70. · Chronic Inflammation and Pathology