General Pathology: Aging

General Pathology: Aging — Expert Reference

How it begins

Análisis exhaustivo de los mecanismos moleculares, celulares y sistémicos del envejecimiento. Desde los hallmarks de López-Otín hasta las correlaciones clínicas en síndromes de envejecimiento acelerado, inflammaging y estrategias senolíticas.

What it covers

1. Conceptualization of Aging
2. · Defining Characteristics (Medawar-Kirkwood Criteria)
3. · Longevity, Life Expectancy and Maximum Life
4. The 12 Hallmarks of Aging
5. Telomeres, Telomerase and Telomeric Attrition
6. · The End-End Replication Problem
7. · Telomerase: Structure and Function
8. · Dysfunctional Telomeres: DNA Damage Response (DDR)
9. Cellular Senescence and Secretory Phenotype (SASP)
10. · Senescence Inducers
11. · Phenotypic Characteristics of the Senescent Cell
12. · The SASP — Secretory Phenotype Associated with Senescence
13. · SASP regulation: NF-κB, mTOR and cGAS-STING
14. · The Double Role of Senescence: Protection vs. Pathology
15. Mitochondrial Dysfunction and Oxidative Stress
16. · Mitochondrial ROS Production
17. · Mitochondrial DNA (mtDNA) vulnerability
18. · Decline of Mitochondrial Biogenesis
19. · Mitophagy Failure
20. Master Pathways of Aging Signaling
21. · Via Insulin / IGF-1 (IIS)
22. · The mTOR (Mechanistic Target of Rapamycin) Pathway
23. · Sirtuins and NAD⁺
24. · AMPK — Energy Sensor and Longevity Promoter
25. Epigenetics of Aging and Biological Clocks
26. · DNA Methylation and Aging
27. · Horvath's Epigenetic Clock
28. · Histones: Chromatin Modifications and Remodeling
29. · Epigenetic Reprogramming: The Yamanaka Experiment and the "Backward Clock"
30. Inflammaging — Chronic Sterile Low Grade Inflammation
31. · Sources of Inflammaging
32. · Pathological Consequences of Inflammaging
33. · Counter-inflammaging: Anti-inflammatory Strategies in Aging
34. Histological and Functional Changes by System
35. · Cardiovascular System
36. · Central Nervous System
37. · Musculoskeletal System
38. · Immune System — Immunosenescence
39. · Skin — The Visible Organ of Aging
40. Accelerated Aging Syndromes (Progeroids)
41. Aging and Oncogenesis
42. · Mechanisms Linking Aging and Cancer
43. Molecular-Based Interventions in Aging
44. · Senolytics in Detail
45. Final Conceptual Integration