Metabolic Syndrome – Applied Clinical Biochemistry

Biochemistry · Basic Sciences

How it begins

Fisiopatología molecular, marcadores bioquímicos, criterios diagnósticos y correlación clínica desde la perspectiva de la bioquímica clínica aplicada.

What it covers

1. Definition and Concept
2. · History and nomenclature
3. · Global epidemiology
4. Diagnostic Criteria
5. · Comparison of historical definitions
6. Central Physiopathology
7. · Adipocins and their biochemical role
8. Insulin Resistance
9. · Normal insulin signaling cascade vs. resistant
10. · Insulin resistance in specific tissues
11. · Clinical measurement of insulin resistance
12. Atherogenic Dyslipidemia
13. · Mechanism: hypertriglyceridemia
14. · Mechanism: low HDL-c + sdLDL
15. · Complete lipid profile in SM
16. · Non-alcoholic fatty liver disease (MAFLD/NAFLD) in SM
17. Hyperglycemia and Progression to DM2
18. · Pancreatic glucotoxicity and lipotoxicity
19. · Incretins in SM
20. · Oral glucose tolerance test (OGTT) in SM
21. Hypertension and Endothelial Dysfunction
22. · Endothelial dysfunction: biochemical mechanisms
23. Low Grade Chronic Inflammation
24. · Inflammatory biomarkers
25. · Activated inflammatory pathways
26. Laboratory Evaluation
27. · Analytical techniques and preanalytical considerations
28. Complications and Cardiovascular Risk
29. · Accelerated atherogenesis in SM: molecular sequence
30. · Global cardiovascular risk stratification
31. Treatment and Molecular Targets
32. · Lifestyle modification: biochemical bases
33. · Pharmacotherapy: molecular targets
34. · Therapeutic goals by component