Epistemis

Pain Medicine Treatise: Chronic Non-Oncological Pain — Multidimensional Approach and Interventionism

Pain Medicine · Clinical Specialties

How it begins

Un compendio exhaustivo y de nivel de subespecialidad médica sobre los sustratos moleculares, la fisiopatología, la evaluación de precisión y las estrategias intervencionistas de vanguardia en los principales síndromes dolorosos de difícil manejo.

What it covers

  1. Chronic Non-Oncological Pain
  2. Neurobiology and Pathophysiology of Chronic Pain
  3. · Nociceptive Transduction Mechanisms
  4. · Peripheral Sensitization: The Inflammatory Soup
  5. · Central Awareness: The "Wind-up" Mechanism and LTP
  6. · The Tripartite Synapse: Microglial and Astrocytic Activation
  7. · Descending Modulatory Pathways: The Balance of Inhibition and Facilitation
  8. Multidimensional Pain Assessment
  9. · Quantitative Sensory Assessment (QST)
  10. · Multidimensional Measurement Scales
  11. Lumbar, Cervical and FBSS/PSPS Radiculopathy
  12. · Mechanism of Endoneural Ischemia and Edema
  13. · Post-surgical Persistent Spinal Pain Syndrome (PSPS Type 2 / FBSS)
  14. Facet Syndrome and Sacroiliac Involvement
  15. · Facet Joint Syndrome (Zygapophyseal Arthritis)
  16. · Sacroiliac Joint Dysfunction
  17. · Facet Precision Locking Algorithm
  18. Complex Regional Pain Syndrome (CRPS)
  19. · Three-Dimensional Pathophysiology of CRPS
  20. · Budapest Clinical Diagnostic Criteria (IASP Consensus)
  21. · Cortical Somatocognitive Reorganization
  22. Common Clinical Neuropathies
  23. · Painful Diabetic Neuropathy (NDD)
  24. · Postherpetic Neuralgia (PHN)
  25. · Chemotherapy-Induced Neuropathy (CIPN)
  26. Craniofacial Neuralgias
  27. · Pathogenesis of Neurovascular Conflict (Classical NT)
  28. · Glossopharyngeal and Occipital Neuralgia (Arnold)
  29. · Trigeminal Autonomic Headaches (CAT)
  30. Post-Stroke Central Pain and Spinal Cord Injury
  31. · Post-Stroke Central Pain Syndrome (Dejerine-Roussy)
  32. · Central Pain due to Spinal Cord Injury (DLM)
  33. Fibromyalgia and Collective Central Sensitization
  34. · Pathophysiology of Central Amplification
  35. · ACR Diagnostic Criteria 2010/2016 (American College of Rheumatology)
  36. Myofascial Pain Syndrome
  37. · Simons' Integrated Hypothesis for PGMs
  38. · Active vs. Latent Trigger Points
  39. Chronic Pelvic Pain
  40. · Viscerosomatic Convergence in the Posterior Horn
  41. · Pudendal Nerve Entrapment Syndrome
  42. · Interstitial Cystitis / Painful Bladder Syndrome
  43. High Specialty Pharmacotherapy in Chronic Pain
  44. · Gabapentinoids: Ligands of the Alpha-2-Delta Subunit (α₂-δ)
  45. · Dual Antidepressants (SNRI) and Tricyclic Antidepressants (TCA)
  46. · The Great Clinical-Scientific Debate: Opioids in Non-Oncological Pain
  47. · Pharmacotherapeutic Guide to Specific Molecules
  48. Interventionist Procedures and Blockades
  49. · Precision Transforaminal Epidural Block
  50. · Radio Frequency (RF) Conventional vs. Pulsed
  51. Neuromodulation and Intrathecal Infusion
  52. · Spinal Cord Stimulation (SCS)
  53. · Cutting-edge Technological Advances in Neuromodulation
  54. · Intrathecal Drug Infusion Systems

The complete study guide is in the app

This page summarizes the outline. The full interactive study guide —with high-yield diagrams, clinical tables, and board review cases— can be read inside Epistemis, completely offline and ad-free.

Subject
Pain Medicine
Category
Clinical Specialties
Type
Study Guide
Sections
54
Reviewed
2026-08-02
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