Epistemis

Treaty on Neurointensivism and Advanced Neuromonitoring | Advanced Medical Library

Intensive Medicine · Clinical Specialties

How it begins

Un compendio exhaustivo y riguroso sobre el manejo del paciente neurocrítico. Desde los mecanismos intrínsecos de autorregulación del flujo sanguíneo cerebral y la dinámica de Monro-Kellie, hasta las fronteras del monitoreo metabólico por microdiálisis, el estado epiléptico refractario, el control de temperatura post-paro, las terapias dirigidas en el trauma craneal grave y la fisiopatología sistémica de la muerte…

What it covers

  1. Neurointensivism and Neurological Support
  2. Applied Brain Physiology and Regulation of Cerebral Blood Flow (CBF)
  3. · 1.1 · Flow-Metabolism Coupling and Oxygen Consumption
  4. · 1.2 · Cerebral Autoregulation: Curves, Limits and Transducer Mechanisms
  5. · 1.3 · The Blood-Brain Barrier (BBB): Ultrastructure and Transport Dynamics
  6. Pathophysiology of Intracranial Hypertension (ICH)
  7. · 2.1 · Extended Monro-Kellie Dynamics and Compliance Curve
  8. · 2.2 · Types of Cerebral Edema: Vasogenic, Cytotoxic, Interstitial and Osmotic
  9. · 2.3 · Cerebral Herniation Syndromes and Tissue Displacement Dynamics
  10. Monitoring of Intracranial Pressure (ICP) and Cerebral Perfusion Pressure (CPP)
  11. · 3.1 · Registration Methods: Intraventricular Catheter vs. Intraparenchymal Sensors
  12. · 3.2 · ICP Wave Analysis: Components and Meaning
  13. · 3.3 · Pathological Lundberg Waves (A, B and C)
  14. · 3.4 · Optimal Cerebral Perfusion Pressure (PPCopt) and the Concept of Dynamic Autoregulation
  15. Advanced Neurophysiological and Metabolic Monitoring
  16. · 4.1 · Oxygen Saturation in the Jugular Bulb (SjvO₂)
  17. · 4.2 · Tissue Oxygen Pressure (PtiO₂)
  18. · 4.3 · Markers of Brain Microdialysis
  19. · 4.4 · Continuous Electroencephalogram (cEEG) in the ICU
  20. · 4.5 · Transcranial Doppler (TCD) and its Hemodynamic Indices
  21. Severe Traumatic Brain Injury (gTBI) and BTF Guidelines
  22. · 5.1 · Pathophysiology: Primary Damage vs. Secondary Damage
  23. · 5.2 · Brain Trauma Foundation (BTF) Guidelines - 4th Edition
  24. · 5.3 · Intracranial Hypertension Treatment Algorithm
  25. Acute Ischemic Cerebrovascular Attack (CVA)
  26. · 6.1 · Pathophysiology of the Core of Ischemic Infarction
  27. · 6.2 · Reperfusion Therapy: Systemic Thrombolysis and Mechanical Thrombectomy
  28. · 6.3 · Blood Pressure Management in Acute Ischemic Stroke
  29. · 6.4 · Malignant Cerebral Infarction of the MCA and Decompressive Craniectomy
  30. Aneurysmal Subarachnoid Hemorrhage (aSAH)
  31. · 7.1 · Clinical and Imaging Stratification (Hunt-Hess and Modified Fisher)
  32. · 7.2 · Definitive Exclusion of Aneurysm: Surgical Clipping vs. Endovascular Coiling
  33. · 7.3 · Critical Complications and Their Pathophysiological Management
  34. Spontaneous Intracerebral Hemorrhage (ICH)
  35. · 8.1 · Pathophysiology: Hematoma Expansion and Perihematomal Edema (PHE)
  36. · 8.2 · Blood Pressure Control: INTERACT2 and ATACH-II Trials
  37. · 8.3 · Immediate Reversal of Specific Coagulopathies
  38. · 8.4 · Surgery in ICH: STICH, STICH II and MISTIE III trials
  39. Convulsive and Nonconvulsive Status Epilepticus (SE)
  40. · 9.1 · Pathophysiology of GABA-A Receptor Refractoriness
  41. · 9.2 · Stepped Pharmacological Treatment Protocol in the ICU
  42. · 9.3 · Super-Refractory Status Epilepticus (SESR)
  43. Anoxic and Hypoxic Encephalopathy Post-Cardiac Arrest
  44. · 10.1 · Pathophysiology of Global Ischemia and Reperfusion Cascade
  45. · 10.2 · Target Temperature Management (TTM)
  46. · 10.3 · Multimodal Neuroprognostic Algorithm
  47. Serious Central Nervous System Infections in the ICU
  48. · 11.1 · Pharmacokinetic Barriers of the Inflamed BBB
  49. · 11.2 · Etiology and Empirical Antibiotic Schemes in the UCIQ
  50. Neuromuscular Crises in the ICU, Dysautonomia and Acquired Weakness
  51. · 12.1 · Intubation and Mechanical Ventilation Criteria: The "20-30-40" Rule
  52. · 12.2 · Autonomic Storm / Cerebral Sympathetic Paroxysm
  53. · 12.3 · Acquired Weakness in the Intensive Care Unit (ICUAW)
  54. Brain Death and Management of Solid Organ Donors
  55. · 13.1 · Clinical Criteria for Diagnosis and Apnea Testing
  56. · 13.2 · Confirmatory Instrumental Tests
  57. · 13.3 · Systemic Pathophysiology of Brain Death
  58. Non-Invasive Neuromonitoring Based on Ultrasonography
  59. · 14.1 · Ultrasound Measurement of the DVNO: Technique and Clinical Thresholds
  60. Systemic Complications of the Neurocritical Patient
  61. · 15.1 · Pathophysiology of Neurogenic Pulmonary Edema (NPE)
  62. · 15.2 · Pathophysiology of Sodium Disorders: CSWS vs. SIADH
  63. Sedoanalgesia, Humanization and Ventilatory Weaning in the Neurocritical Patient
  64. · 16.1 · Propofol, Dexmedetomidine and the Problem of Benzodiazepine Use
  65. · 16.2 · Ventilatory Weaning Algorithm in the Patient with Compromised Airway Reflexes
  66. · 16.3 · Key Principles in the Clinical Practice of Neurointensivism

The complete study guide is in the app

This page summarizes the outline. The full interactive study guide —with high-yield diagrams, clinical tables, and board review cases— can be read inside Epistemis, completely offline and ad-free.

Subject
Intensive Medicine
Category
Clinical Specialties
Type
Study Guide
Sections
66
Reviewed
2026-08-02
Download Epistemis