Clinical Biochemistry — Molecular Basis of Arterial Hypertension

Biochemistry · Basic Sciences

How it begins

Estudio minucioso de la señalización celular, disfunción endotelial, transporte iónico epitelial, genética molecular y mecanismos inmunoinflamatorios involucrados en la génesis y progresión de la hipertensión arterial sistémica.

What it covers

1. Hemodynamics and Tension Homeostasis: Biophysical and Cellular Aspects
2. The Endothelium as an Endocrine and Metabolic Organ: Regulation of Vascular Tone
3. Renin-Angiotensin-Aldosterone System (RAAS): Classical and Counterregulatory Axes
4. AT1 and AT2 Receptors: Structure, Intracellular Signaling and Genomic Interactions
5. Aldosterone and the Mineralocorticoid Receptor: Synthesis, Genomic Regulation and Non-Genomic Effects
6. Ion Channels and Renal Transporters: The Proximal and Interstitial Management of Sodium
7. Tubuloglomerular Feedback Mechanism and the Juxtaglomerular Apparatus
8. Pressure Natriuresis and Renal Interstitial Remodeling
9. Sympathetic Nervous System (SNS): Central Regulation and Adrenergic Coupling
10. Mechanoreceptors, Chemoreceptors and the Arterial Baroreflex: Molecular Dysfunction in HTN
11. Natriuretic Peptide System: Guanylate Cyclase-Coupled Receptors and Degradation Enzymes
12. Kalicrein-Kinin System and Nitric Oxide Synthesis: Metabolic Regulation and Interaction
13. Endothelial Dysfunction and Oxidative Stress: The Uncoupling of eNOS
14. ROS and modulation of NO bioavailability: Nox Enzyme Systems and Chemical Interactions
15. Vasoactive Endothelins and Prostanoids: Molecular Regulation of Constrictor Tone
16. Vascular Remodeling: The Cellular Phenotype of VSMCs
17. Matrix Metalloproteinases, Collagen and the Biochemistry of Arterial Stiffness
18. Monogenic Forms of Hypertension: Electrolyte Transport Variants
19. Genome Complex Association Studies (GWAS) and Epigenetic Regulation
20. Adaptive and Innate Immunity in Hypertension: Activation of T Lymphocytes and Isolevuglandins
21. The Microbiota-Gut-Brain-Kidney Axis in Hypertension
22. Biochemical Biomarkers of Organ Damage and Cardiovascular Prediction
23. Pharmacogenomics and Molecular Targets of Classical Therapies
24. Therapeutic Frontiers: RNA Therapies, Antisense Oligonucleotides and Vaccines
25. Classification and Staging of HTN
26. · Essential HTA (Primary) — 90-95%
27. · Secondary HTN — 5-10%
28. Organic Damage from Arterial Hypertension
29. Secondary Etiologies — Specific Biochemistry
30. Hypertensive Laboratory Study
31. · Initial evaluation - All hypertensive patients
32. · Extended study — secondary HTN / high risk
33. Pharmacological Mechanisms of Antihypertensive Treatment
34. Hypertensive Crisis — Urgency and Emergency
35. · Hypertensive Emergency
36. · Hypertensive Emergency