Clinical Biochemistry: Vitamin D

Biochemistry · Basic Sciences

How it begins

Estudio exhaustivo de la síntesis de secosteroides, hidroxilaciones por citocromos CYP, transporte sérico, transactivación por el VDR, homeostasis mineral y correlaciones clínico-patológicas de precisión.

What it covers

1. Introduction and Chemical Nomenclature
2. · Chemical Structure of the Main Forms
3. Cutaneous Synthesis and Photobiology
4. · The Photochemical and Thermal Reaction
5. · Self-limiting Mechanisms for Photoprotection and Toxicity Prevention
6. Intestinal Absorption and Systemic Incorporation
7. · Assembly and Secretion in Chylomicrons
8. · Kinetics of Vitamin D Binding Protein (DBP / Gc-Globulin)
9. Hepatic Metabolism (25-hydroxylation)
10. · Biochemistry of the CYP2R1 Enzymatic Reaction
11. · Absence of Strict Hepatic Feedback Mechanisms
12. Renal and Extrarenal Metabolism
13. · Multiorgan Endocrine Regulation of Renal 1α-hydroxylase
14. · The Catabolic Pathway: The CYP24A1 Enzyme
15. · Extrarenal 1α-hydroxylation (Autocrine / Paracrine Regulation)
16. The Vitamin D Receptor (VDR) and Molecular Mechanism of Action
17. · Mandatory Heterodimerization Mechanism with the RXR
18. · Recruitment of the Coactivator and Corepressor Complex
19. · Non-Genomic Effects / Rapid Membrane Signaling
20. Systemic Homeostasis of Calcium and Phosphorus
21. · 1. Intestinal Absorption of Calcium and Phosphorus (Duodenum and Jejunum)
22. · 2. Active Renal Calcium Reabsorption (Distal Convoluted Tubule)
23. · 3. Bone Mineral Metabolism and Remodeling
24. Pleiotropic Effects / Non-Classical Actions
25. Pathophysiology of Deficit States
26. · Primary Etiologies of Vitamin D Deficiency
27. Genetic Disorders of the Vitamin D Axis
28. Laboratory Diagnosis and Analytical Methodology
29. · Analytical Determination Methodologies
30. · Standardization and Ranges of Nutritional Sufficiency
31. Vitamin D Toxicity (Hypervitaminosis)
32. · Pathophysiology of Molecular Damage
33. · Medical Treatment Scheme for Acute Toxicity
34. Pharmacology and Supplementation Guides
35. · Clinical Dosing and Loading Strategies
36. Physiological Integration of the Endocrine Axis