Clinical Biochemistry of Neurological Diseases | Treaty of Neurochemistry and Molecular Diagnostics

Biochemistry · Basic Sciences

How it begins

Un análisis exhaustivo sobre los mecanismos moleculares que rigen las patologías del sistema nervioso central y periférico. Desde la cinética de translocación proteica y las proteopatías amiloidogénicas, hasta el estudio cuantitativo del líquido cefalorraquídeo mediante electroenfoque, espectrometría de masas de biomarcadores plasmáticos y la genética molecular de las canalopatías.

What it covers

1. Neurological Clinical Biochemistry
2. Blood Brain Barrier (BBB) and Biochemical Analysis of CSF
3. · 1.1 · Protein Structure of Tight Junctions and Transport System
4. · 1.2 · Biochemistry of CSF Production and Composition
5. · 1.3 · Diagnostic Biochemical Parameters in CSF
6. Neurodegenerative Diseases I: Amyloid Proteopathies (Alzheimer's)
7. · 2.1 · Amyloid Precursor Protein (APP) Processing
8. · 2.2 · Amyloid Cascade Hypothesis and Tau Pathology
9. · 2.3 · Biochemical Biomarkers of Alzheimer's in Clinic
10. Neurodegenerative Diseases II: Synucleinopathies and Lysosomal Dysfunction
11. · 3.1 · Conformational Dynamics and Aggregation of α-synuclein
12. · 3.2 · Aggregate Seeding Tests in Diagnostics: RT-QuIC
13. Motoneuron Diseases and Systemic Atrophies: ALS and Huntington's
14. · 4.1 · Amyotrophic Lateral Sclerosis: Mechanisms of TDP-43 and C9orf72 Toxicity
15. · 4.2 · Huntington's Disease: Biochemistry of the Polyglutamine Domain
16. Multiple Sclerosis and Neuroimmune Demyelinating Diseases
17. · 5.1 · Immunochemical Physiopathology of Demyelinating Plaque
18. · 5.2 · Isoelectrofocusing of CSF and Detection of Oligoclonal Bands (BOC)
19. · 5.3 · Differential Diagnosis of NMOSD and MOGAD
20. Molecular Pathophysiology of Cerebral Ischemia and Acute Biomarkers
21. · 6.1 · Pathophysiology of Ischemic Cellular Injury
22. · 6.2 · Biochemical Markers of Acute Brain Injury
23. Chanalopathies, Epileptogenesis and Neurotransmission
24. · 7.1 · Physiology of Excitatory Neurotransmission vs. inhibitory
25. · 7.2 · Molecular Physiopathology of SCN1A Sodium Channel Channelopathies
26. · 7.3 · Dynamics of Intracellular Chlorine in Acquired Epileptogenesis
27. Metabolic, Toxic and Nutritional Encephalopathies
28. · 8.1 · Hepatic Encephalopathy: Ammonia Metabolism and Astrocytic Edema
29. · 8.2 · Nutritional Encephalopathies: Wernicke-Korsakoff and Combined Degeneration
30. Mitochondrial Dysfunction and Energy Metabolism Diseases
31. · 9.1 · Physiology of the Electron Transport Chain (OXPHOS)
32. · 9.2 · Diagnostic Biochemistry: Lactic Acidosis and the Lactate/Pyruvate Ratio
33. Pathophysiology and Biochemistry of Prion Diseases
34. · 10.1 · Structural Transition from PrPC to PrPSc
35. · 10.2 · Prion Disease Biomarker Panel in CSF
36. Biochemical Markers and Molecular Genetics in Neuro-oncology
37. · 11.1 · IDH1/IDH2 Mutation and the 2-Hydroxyglutarate Oncometabolite Pathway
38. · 11.2 · 1p/19q Codeletion and MGMT Promoter Methylation Status
39. · 11.3 · Paraneoplastic Neurological Syndromes and Autoantibodies
40. Lysosomal and Fatty Acid Storage Diseases (VLCFA)
41. · 12.1 · Sphingolipidosis: Enzymatic Physiopathology of Gaucher, Tay-Sachs and Niemann-Pick
42. · 12.2 · X-Linked Adrenoleukodystrophy (X-ALD): Biochemistry of VLCFAs
43. · 12.3 · Profile of Very Long Chain Fatty Acids in Laboratory Diagnostics