Clinical Biochemistry · Respiratory Diseases

Biochemistry · Basic Sciences

How it begins

Una inmersión exhaustiva en los procesos moleculares, termodinámicos y celulares que rigen la fisiología pulmonar y sus desviaciones patológicas. Este documento integra la fisiología de gases y el equilibrio ácido-base con el estudio ultraestructural y genético de las principales patologías del parénquima y de la vasculatura pulmonar.

What it covers

1. Biophysics of gas exchange and transport
2. · Hemoglobin kinetics and allosterism
3. · Biochemical affinity modulators: Bohr, Haldane and 2,3-BPG
4. Acid-base balance of respiratory origin
5. · CO₂ hydration dynamics and catalyzed hydration
6. · Molecular pathophysiology of respiratory disorders
7. Biochemistry of pulmonary surfactant
8. · Lipid structure: dipalmitoylphosphatidylcholine (DPPC)
9. · Surfactant apoproteins (SP-A, SP-B, SP-C, SP-D)
10. Molecular immunobiology of asthma
11. · The Th2 / T2-high cascade
12. · Molecular pathophysiology of lipid mediators
13. Oxidative stress and proteolysis in COPD
14. · Oxidative stress: Free radicals and cellular senescence
15. Alpha-1 antitrypsin (AAT) deficiency
16. · The Serpine Superfamily and structure of the AAT
17. · Genetic variants and aberrant polymerization
18. Cystic fibrosis and CFTR molecular dysfunction
19. · Structure and biophysics of the CFTR channel
20. · Biochemical classification of CFTR mutations
21. Acute respiratory distress syndrome (ARDS)
22. · Mechanisms of diffuse alveolar damage (DAD)
23. Diagnostic biochemistry of pleural effusion
24. · Light's criteria and biochemical differentiation
25. · Specific biomarkers in pleural fluid
26. Pulmonary thromboembolism and tissue ischemia
27. · The coagulation cascade and the genesis of D-Dimer
28. · Biomarkers of right myocardial overload and damage
29. Cellular pathophysiology of pneumoconiosis and inhalation toxicity
30. · Silicosis and activation of the NLRP3 inflammasome
31. · Asbestosis and the Fenton reaction
32. Biomarkers and oncogenomics of lung cancer
33. · Lung Adenocarcinoma Genomics
34. · Immunotherapy and the PD-1/PD-L1 axis
35. · Traditional serum biological markers
36. Respiratory infections and biomarkers of inflammatory response
37. · Procalcitonin (PCT) versus C-Reactive Protein (CRP)
38. EPID and aberrant extracellular matrix remodeling
39. · Mechanisms of Fibrogenesis and Signaling by TGF-β
40. · Biomarkers of interstitial epithelial damage
41. Endothelial dysfunction and pulmonary arterial hypertension
42. · Dysfunctional molecular pathways
43. Acute respiratory failure, tissue hypoxia and lactate clearance
44. · Physiology of anaerobic metabolism and hyperlactatacidemia
45. Synthesis and integrated pulmonological differential diagnosis
46. · Integrated algorithmic interpretation of arterial blood gases
47. · Summary atlas of pleural fluid profiles