Clinical Biochemistry: Minimal Residual Disease (MRD) - Reference Treatise on Laboratory and Molecular Pathology

Biochemistry · Basic Sciences

How it begins

Persistencia clonal subclínica, caracterización del nicho de resistencia, metodologías de alta resolución por citometría de flujo multiparamétrica, PCR digital (dPCR) y secuenciación masiva dirigida (NGS/biopsia líquida). Fundamentos analíticos y guías de toma de decisión para la medicina de precisión oncohematológica.

What it covers

1. · Molecular Architecture and Biology of the Resistance Niche
2. · Physical Principles and Instrumentation of High Resolution Cytometry
3. · Real-Time Quantitative Polymerase Chain Reaction (RT-qPCR)
4. · Digital Droplet PCR (ddPCR): Absolute and High Sensitivity Quantification
5. · Methodological Strategies in High Sensitivity Genomics
6. · Precursor Acute Lymphoblastic Leukemia B (B-ALL)
7. · Acute Myeloid Leukemia (AML): Challenges of Clonal Heterogeneity
8. · Multiple Myeloma: From Complete Remission to Negative MRD
9. · Diffuse Large B Cell Lymphoma (DLBCL) and Follicular Lymphoma
10. · Analytical Models in Solid Tumors: Tumor-Informed and Tumor-Naive Approaches
11. · The Golden Rule of the First Bone Marrow Aspirate
12. · Evidence in International Clinical Trials
13. · Clinical Strategies Based on EMR Status
14. · Instrumental Innovations in Development