Immunopathology — General Pathology

General Pathology · Basic Sciences

How it begins

La inmunopatología estudia las enfermedades que resultan de respuestas inmunes anómalas: excesivas (hipersensibilidad, autoinmunidad), mal dirigidas (respuestas contra autoantígenos o agentes inofensivos) o insuficientes (inmunodeficiencias). El sistema inmune es el guardián del organismo frente a los patógenos, pero su desregulación es el sustrato de algunas de las enfermedades más devastadoras y prevalentes de la…

What it covers

1. Immunopathology
2. Concept and Immune System
3. · Innate Immunity — The Front Line
4. · Adaptive Immunity — The Second Line
5. Immunological Tolerance
6. · Immune Checkpoints
7. Hypersensitivity — Concept and Classification
8. Type I Hypersensitivity — Immediate / Allergic
9. · Pathophysiology — Two Necessary Expositions
10. · Clinical Manifestations
11. Type II Hypersensitivity — Cytotoxic
12. · Type II Hypersensitivity Diseases
13. Type III Hypersensitivity — Immune Complexes
14. · Pathogenesis — Formation and Deposition of Immune Complexes
15. · Experimental Models and Human Diseases
16. · Type III Hypersensitivity Diseases
17. Type IV Hypersensitivity — Cellular / Delayed
18. · Clinical Models of Type IV Hypersensitivity
19. Autoimmunity — Pathogenesis
20. · Tolerance Breaking Mechanisms
21. · Autoantibodies — Fundamental Diagnostic Tool
22. Systemic Lupus Erythematosus (SLE)
23. · EULAR/ACR Classification Criteria 2019
24. · Lupus Nephritis — ISN/RPS Classification
25. Rheumatoid Arthritis (RA)
26. · Pathogenesis — The Synovial Pannus
27. · Biological Therapeutic Targets in RA — Based on Pathogenesis
28. Sjögren's syndrome
29. Scleroderma — Systemic Sclerosis (SSc)
30. · Pathogenesis — The Pathophysiological Triad
31. Inflammatory Myopathies
32. Other Relevant Autoimmune Diseases
33. Immunodeficiencies — Concept
34. Primary Immunodeficiencies
35. HIV / AIDS
36. · Virology and Life Cycle of HIV
37. · Replicative Cycle
38. · Natural History of HIV Infection
39. · AIDS Defining Diseases (CD4 200/μL)
40. · ART — Antiretroviral Therapy
41. Secondary Immunodeficiencies
42. Transplant Rejection
43. · Allorecognition Mechanisms
44. · Types of Rejection
45. · Immunosuppression in Transplantation
46. · Graft Versus Host Disease (GVHD/GvHD)
47. Oncological Immunotherapy
48. · Tumor Escape — Why the Immune System Does Not Destroy the Tumor
49. · Types of Oncological Immunotherapy
50. · Immune-mediated Adverse Effects (irAE)
51. Integration and Final Perspective
52. · Conceptual Map of Immunopathology
53. · Therapeutic Connections — From Pathogenesis to Drug
54. · Final Summary — Key Concepts
55. · Bibliographical References